CAJ | 학술논문

目的探讨血清NO、一氧化氮合成酶(NOS)活力与抑郁症的关系.方法纳入136例符合中国精神障碍分类与诊断标准的抑郁症患者(实验组)和120名健康志愿者(对照组),进行血清NO水平及NOS活力的检测,并进行对照分析.结果实验组血清NO水平(70.05±10.34)μmol/L及NOS活力平均水平(29.49±5.12)U/L均高于正常对照组[(67.17±16.52)μmol/L、(26.99±2.87)U/L],差异均有统计学意义(P均<0.05);抑郁症患者中服药组血清NO水平(74.42±8.80)μmol/L及NOS活力平均水平(27.71±5.46)U/L均低于未服药组[(78.81±12.28)μmoL/L、(30.49±4.65)U/L],两者相比,差异有统计学意义(P均<0.05).结论抑郁症患者血清NO水平及NOS活力升高,NO升高可能是抑郁症发病的影响因素;抗抑郁药可能通过降低血清NO水平而起到抗抑郁作用.
목적 탐토혈청NO、일양화담합성매(NOS)활력여억욱증적관계.방법 납입136례부합중국정신장애분류여진단표준적억욱증환자(실험조)화120명건강지원자(대조조),진행혈청NO수평급NOS활력적검측,병진행대조분석.결과 실험조혈청NO수평(70.05±10.34)μmol/L급NOS활력평균수평(29.49±5.12)U/L균고우정상대조조[(67.17±16.52)μmol/L、(26.99±2.87)U/L],차이균유통계학의의(P균<0.05);억욱증환자중복약조혈청NO수평(74.42±8.80)μmol/L급NOS활력평균수평(27.71±5.46)U/L균저우미복약조[(78.81±12.28)μmoL/L、(30.49±4.65)U/L],량자상비,차이유통계학의의(P균<0.05).결론 억욱증환자혈청NO수평급NOS활력승고,NO승고가능시억욱증발병적영향인소;항억욱약가능통과강저혈청NO수평이기도항억욱작용.
Objective To measure the correlation between the levels of blood serum nitric oxide(NO) ,the activity of nitric oxide synthetase(NOS) and depression.Methods 136 patients with depression were diagnosed by CCMD-3 and 120 healthy control subjects were included in the study.NO and NOS levels in blood serum of both groups were tested, and the variation of NO and NOS between the two groups were compared.Results The blood se-rum NO levels[ (70.05±10.34)μmol/L w.(67.17±16.52) μmol/L] and the activity of NOS [(29.49±5.12)U/L vs.(26.99±2.87) U/L] in the patients with depression were significantly higher than those in the control group(P<0.05).The blood serum NO levels and the activity NOS in the treatment patients was lower than the oth-er patients[(74.42±8.80) μmol/L vs.(78.81±12.28) μmol/L;(27.71±5.46)U/L vs.( 30.49±4.65 )U/L,P <0.05].Conclusion The blood serum NO levels and the activity of NOS increase in the patients with de-pression.NO might be involved in the pathogenesis of depression.The antidepressants might descend the NO levels so to relieving depression.