中国医药
中國醫藥
중국의약
CHINA MEDICINE
2011年
z1期
9-11
,共3页
胃肠肿瘤%糖类抗原724%糖类抗原19-9%癌胚抗原
胃腸腫瘤%糖類抗原724%糖類抗原19-9%癌胚抗原
위장종류%당류항원724%당류항원19-9%암배항원
Gastric tumor%Carbohydrate antigen 72-4%Carbohydrate antigen 19-9%Carcinoembryonic antigen
目的 探讨胃液及血清癌胚抗原(CEA)和糖类抗原(CA)72-4、CA19-9联合检测对胃癌的诊断价值.方法 免疫放射测定检测64例各期胃癌和40例良性胃病患者胃液和血清中CA72-4,CA19-9和CEA水平及灵敏度.结果 64例胃癌组患者胃液和血清中CA72-4,CA19-9和CEA水平及灵敏度明显高于良性胃病组；胃癌组胃液CA72-4,CA19-9和CEA测定值平均水平明显高于其血清水平[(60.4±23.5) μg/L比(13.8±3.2)μg/L,(524.4±284.6) μg/L比(97.3±67.3) μg/L,(16.8±7.8) μg/L比(5.3±8.3)μg/L]；胃液CEA、血清CA19-9、血清CA72-4联合检测灵敏度和准确率最高；晚期胃癌患者胃液和血清CA72-4,CA19-9水平和灵敏度高于早期胃癌.结论 肿瘤标志物联合检测不仅可提高胃癌的早期诊断率,还能提示肿瘤的扩散和转移、判断预后.
目的 探討胃液及血清癌胚抗原(CEA)和糖類抗原(CA)72-4、CA19-9聯閤檢測對胃癌的診斷價值.方法 免疫放射測定檢測64例各期胃癌和40例良性胃病患者胃液和血清中CA72-4,CA19-9和CEA水平及靈敏度.結果 64例胃癌組患者胃液和血清中CA72-4,CA19-9和CEA水平及靈敏度明顯高于良性胃病組；胃癌組胃液CA72-4,CA19-9和CEA測定值平均水平明顯高于其血清水平[(60.4±23.5) μg/L比(13.8±3.2)μg/L,(524.4±284.6) μg/L比(97.3±67.3) μg/L,(16.8±7.8) μg/L比(5.3±8.3)μg/L]；胃液CEA、血清CA19-9、血清CA72-4聯閤檢測靈敏度和準確率最高；晚期胃癌患者胃液和血清CA72-4,CA19-9水平和靈敏度高于早期胃癌.結論 腫瘤標誌物聯閤檢測不僅可提高胃癌的早期診斷率,還能提示腫瘤的擴散和轉移、判斷預後.
목적 탐토위액급혈청암배항원(CEA)화당류항원(CA)72-4、CA19-9연합검측대위암적진단개치.방법 면역방사측정검측64례각기위암화40례량성위병환자위액화혈청중CA72-4,CA19-9화CEA수평급령민도.결과 64례위암조환자위액화혈청중CA72-4,CA19-9화CEA수평급령민도명현고우량성위병조；위암조위액CA72-4,CA19-9화CEA측정치평균수평명현고우기혈청수평[(60.4±23.5) μg/L비(13.8±3.2)μg/L,(524.4±284.6) μg/L비(97.3±67.3) μg/L,(16.8±7.8) μg/L비(5.3±8.3)μg/L]；위액CEA、혈청CA19-9、혈청CA72-4연합검측령민도화준학솔최고；만기위암환자위액화혈청CA72-4,CA19-9수평화령민도고우조기위암.결론 종류표지물연합검측불부가제고위암적조기진단솔,환능제시종류적확산화전이、판단예후.
Objective To explore the clinical value of combined testing of carbohydrate antigen(CA)72-4,CA19-9 and carcinoembryonic antigen(CEA) in gastric cancer.Methods The gastric juice and serum levels of CA72-4,CA19-9 and CEA in 64 cases of al1stages of gastric cancer and 40 cases of benign gastric disorders were determined preoperatively using IRMA method.Results The results showed that the gastric juice,serum levels and the sensitivity rates of CA72-4,CA19-9 and CEA were significantly higher in the gastric cancer group than in the benign gastric disorders group.The gastric juice levels of CA72-4,CA19-9 and CEA were also higher than the serum levels in the gastric cancer group[ (60.4 ±23.5) μg/L vs (13.8 ±3.2) μg/L,(524.4 ±284.6) μg/L vs (97.3 ±67.3 ) μg/L,( 16.8 ± 7.8 ) μg/L vs ( 5.3 ± 8.3 ) μg/L ].The sensitivity rate of combining assay of gastric juice CA19-9,serum CA19-9 and serum CA72-4 was 78.13％.The gastric juice and serum levels of CA72-4,CA19-9 and sensitivity in progressive and late stage of gastric cancer were higher than those in early stage.Conclusion The reasonable preoperative combining test might be of high value for early diagnosis,predicting the diffusion and metastasis,improving the therapeutic effect and prognosis for gastric cancer.
