CAJ | 학술논문

目的观察错配修复基因hMLH1在膀胱移行细胞癌中的表达,探讨hMLH1与膀胱移行细胞癌的关系.方法通过免疫组织化学方法测定hMLH1在80例膀胱移行细胞癌中及20例正常膀胱组织中的表达.结果 hMLH1在膀胱移行细胞癌中的低表达率(32.5%)明显高于在正常膀胱组织中的低表达率(0%),差异有统计学意义(P＜0.05),且hMLH1在膀胱移行细胞癌中的低表达与肿瘤的分期分级有关(P＜0.05).结论 hMLH1的低表达与膀胱移行细胞癌的发生有关,与肿瘤的高分期和高分级有关,hMLH1的低表达在浸润性及分化差的膀胱移行细胞癌多见.
목적 관찰착배수복기인hMLH1재방광이행세포암중적표체,탐토hMLH1여방광이행세포암적관계.방법 통과면역조직화학방법 측정hMLH1재80례방광이행세포암중급20례정상방광조직중적표체.결과 hMLH1재방광이행세포암중적저표체솔(32.5%)명현고우재정상방광조직중적저표체솔(0%),차이유통계학의의(P＜0.05),차hMLH1재방광이행세포암중적저표체여종류적분기분급유관(P＜0.05).결론 hMLH1적저표체여방광이행세포암적발생유관,여종류적고분기화고분급유관,hMLH1적저표체재침윤성급분화차적방광이행세포암다견.
Objective To study the expressions and significance of DNA mismatch repair gene hMLH1 protein in transitional cell carcinoma of bladder.Methods Immunohistochemistry was used to detect the expressions of hMlH1 in 80 cases of transitional cell carcinoma of bladder.20 cases of normal bladder tissues.Results Reduced expression rate of hMLHl in transitional cell carcinoma of bladder was 32.5%,significantly higher than that in control group(0%)(P＜0.05).The low expression of hMLH1 in transitional cell carcinoma of bladder was also correlated to clinical grade and stage(P＜0.05).Condusion Reduced expression of hMLH1 may play an important role in carcinogenesis and developmem of transitional cell carcinoma of bladder.