CAJ | 학술논문

目的观察125I粒子覆膜食管支架对于正常兔食管组织的放射性损伤.方法将实验用兔分两组,每组各6只,实验组置入125I粒子支架(单颗粒子剂量22.2MBq ×3颗粒子),对照组植入无放射粒子的支架.于支架植入后2、4、8周分别取实验组和对照组兔2只,行食管造影,观察支架、粒子移位情况,处死后取标本行肉眼、显微镜观察.结果支架释放过程及术后随访未发现125I粒子脱落.所有动物未发现穿孔等严重并发症.实验组术后2周,食管中部仅为轻微的病理学损伤,鳞状上皮明显增生.黏膜卜炎性细胞浸润.术后4周,出现肉芽组织增生,少量纤维组织增生.术后8周,肉芽组织、纤维结缔组织进一步增生.粒子相对处的食管组织损伤程度明显轻于粒子接触处食管组织.对照组支架中间部分食管与正常食管组织相似,可见食管鳞状卜皮轻增生.支架两端实验组和对照组局部增生食管组织覆盖支架,可见肉芽组织、纤维结缔组织明显增牛.结论 125I粒子支架置人正常兔食管壁组织造成病理性改变,主要表现为肉芽组织、纤维结缔组织增生,无出血、穿孔.
목적 관찰125I입자복막식관지가대우정상토식관조직적방사성손상.방법 장실험용토분량조,매조각6지,실험조치입125I입자지가(단과입자제량22.2MBq ×3과입자),대조조식입무방사입자적지가.우지가식입후2、4、8주분별취실험조화대조조토2지,행식관조영,관찰지가、입자이위정황,처사후취표본행육안、현미경관찰.결과 지가석방과정급술후수방미발현125I입자탈락.소유동물미발현천공등엄중병발증.실험조술후2주,식관중부부위경미적병이학손상,린상상피명현증생.점막복염성세포침윤.술후4주,출현육아조직증생,소량섬유조직증생.술후8주,육아조직、섬유결체조직진일보증생.입자상대처적식관조직손상정도명현경우입자접촉처식관조직.대조조지가중간부분식관여정상식관조직상사,가견식관린상복피경증생.지가량단실험조화대조조국부증생식관조직복개지가,가견육아조직、섬유결체조직명현증우.결론 125I입자지가치인정상토식관벽조직조성병이성개변,주요표현위육아조직、섬유결체조직증생,무출혈、천공.
Objective To evaluate the tissue response to the covered metallic stent loaded with radioactive 125I seeds in normal rabbit esophagus.Methods Twelve rabbits were randomlv assigncd into 2 groups.A covered metallic stent loaded with three 125I seeds set in sheaths Was implanted into the esophagus of the rabbit from experimental group(22.2 MBq for each seed,n=6).The rabbits of control group were implanted with stent without 125I (n=6).Two rabbits from each group underwent esophagus X-ray examination to detect migration of the stent and the 125I seeds at 2,4 and 8 weeks after stent implantation,respectively.And the animals were then sacrificed to observe the changes in esophagus.Results No 125I seed migration Was found during and after the implantation of the stent.No esophageal perforation was observed.Two weeks after stent implantation,such mild lesions were observed in the middle of the esophagus in experimental group as slight epithelial hyperplasia and submucosal inflammation.At 4th week after stentimplantation,granulation and fibrosis were observed,which became more obvious at 8th week after the procedure.The injury of esophageal tissue opposite to the 125I seed Was significantly milder than that of the tissue exposed to 125I seed.In control group,esophagus adjacent to the middle of the stent WaS similar to normal tissue,with slight epithelial hyperplasia.However,both ends of the stent were covered with marked hyperplasia epithelium in both groups,and severe granulation and fibrosis could be observed.Conclusion The main pathological changes of esophagus wall adjacent to the 125I seed are granulation and fibrosis.No bleeding or perforation occurs.