中华医学杂志
中華醫學雜誌
중화의학잡지
National Medical Journal of China
2011年
18期
1246-1249
,共4页
徐向东%卢向红%施勇%叶冠雄%朱锡元
徐嚮東%盧嚮紅%施勇%葉冠雄%硃錫元
서향동%로향홍%시용%협관웅%주석원
纤维蛋白组织粘着剂%顺铂%迟效制剂%药代动力学
纖維蛋白組織粘著劑%順鉑%遲效製劑%藥代動力學
섬유단백조직점착제%순박%지효제제%약대동역학
Fibrin tissue adhesive%Cisplatin%Delayed action preparations%Pharmacokinetics
目的 探讨纤维蛋白胶顺铂凝胶化疗的缓释特性.方法 体内释放实验中,将顺铂和纤维蛋白胶混合成凝胶20例为实验组,单纯顺铂化疗20例为对照组,定时取少量外周血和尿液作样本,测试样本中顺铂浓度,计算外周血及尿液中顺铂的动力学参数.结果 体内实验显示,外周血顺铂峰浓度实验组和对照组分别为(192.2±33.5)μg/L、(1077.6±176.6)μg/L,实验组显著低于对照组(P<0.01);尿液顺铂峰浓度实验组和对照组分别为(18.6 4-8.7)μg/L、(55.8±12.7)μg/L,实验组显著低于对照组(P<0.01),外周血实验组的消除半衰期为23.32 h,而对照组为13.93 h,外周血及尿液中的顺铂消除半衰期及曲线下面积实验组均明显长于或大于对照组(P<0.01).结论 在体内条件下纤维蛋白胶顺铂凝胶具有良好的缓释性,在腹腔局部使用,可延长顺铂在腹腔的滞留时间,降低外周血的铂类浓度.
目的 探討纖維蛋白膠順鉑凝膠化療的緩釋特性.方法 體內釋放實驗中,將順鉑和纖維蛋白膠混閤成凝膠20例為實驗組,單純順鉑化療20例為對照組,定時取少量外週血和尿液作樣本,測試樣本中順鉑濃度,計算外週血及尿液中順鉑的動力學參數.結果 體內實驗顯示,外週血順鉑峰濃度實驗組和對照組分彆為(192.2±33.5)μg/L、(1077.6±176.6)μg/L,實驗組顯著低于對照組(P<0.01);尿液順鉑峰濃度實驗組和對照組分彆為(18.6 4-8.7)μg/L、(55.8±12.7)μg/L,實驗組顯著低于對照組(P<0.01),外週血實驗組的消除半衰期為23.32 h,而對照組為13.93 h,外週血及尿液中的順鉑消除半衰期及麯線下麵積實驗組均明顯長于或大于對照組(P<0.01).結論 在體內條件下纖維蛋白膠順鉑凝膠具有良好的緩釋性,在腹腔跼部使用,可延長順鉑在腹腔的滯留時間,降低外週血的鉑類濃度.
목적 탐토섬유단백효순박응효화료적완석특성.방법 체내석방실험중,장순박화섬유단백효혼합성응효20례위실험조,단순순박화료20례위대조조,정시취소량외주혈화뇨액작양본,측시양본중순박농도,계산외주혈급뇨액중순박적동역학삼수.결과 체내실험현시,외주혈순박봉농도실험조화대조조분별위(192.2±33.5)μg/L、(1077.6±176.6)μg/L,실험조현저저우대조조(P<0.01);뇨액순박봉농도실험조화대조조분별위(18.6 4-8.7)μg/L、(55.8±12.7)μg/L,실험조현저저우대조조(P<0.01),외주혈실험조적소제반쇠기위23.32 h,이대조조위13.93 h,외주혈급뇨액중적순박소제반쇠기급곡선하면적실험조균명현장우혹대우대조조(P<0.01).결론 재체내조건하섬유단백효순박응효구유량호적완석성,재복강국부사용,가연장순박재복강적체류시간,강저외주혈적박류농도.
Objective To summarize the sustained dynamic release characteristics of fibrin glue enwrapping cisplatin.Methods In this in vivo study,20 patients received fibrin glue enwrapping cisplatin placed into the abdominal cavity while another 20 patients received cisplatin as the control group.Their peripheral blood and urine samples were collected at a regular interval to determine the concentrations and the pharmacokinetic parameters of cisplatin.Results The peak peripheral blood concentration of cisplatin in the study group was significantly lower than that in the control group[(192.2±33.5)vs(1077.6±176.6)μg/L,P<0.01].And the peak urine concentration of cisplatin Was significantly lower in the study group than that in the control group[(18.6±8.7)vs(55.8±12.7)μg/L,P<0.01].The elimination half-life of cisplatin was 23.32 h and 13.93 h respectively in the study and control groups.The elimination half-life and the area under the curve in peripheral blood and urine samples of the study group were significantly longer than those of the control group(P<O.01).Conclusion The fibrin glue enwrapping cisplatin has the excellent in vivo characteristics of sustained dynamic release.Thus it may prolong the retention of cisplatin in abdominal cavity and lower its concentration in peripheral blood.
