CAJ | 학술논문

目的比较苏木精与丝裂霉素、顺铂、羟喜树碱等药物腹腔化疗对小鼠肝癌腹水型HepA细胞的抑制作用,探讨苏木精临床腹腔化疗的可行性.方法腹腔内接种HepA细胞,建立小鼠肝癌腹水瘤模型,接种后24 h开始腹膜腔内注射给药,给药结束后动物常规饲养,定期测量小鼠体重,观察各组动物的生存状态,比较各组动物的平均生存时间.实验重复3次,比较3次实验的T/C值.结果对照组动物的平均生存时间为15.99～16.33 d;苏木精组为36.35～39.81 d;丝裂霉素组为35.77～40.06 d;羟喜树碱组为20.79～38.47 d;顺铂组为32.98～41.89 d.综合比较以丝裂霉素组和苏木精组效果较好.结论苏木精腹腔化疗对小鼠移植性肝癌HepA细胞有显著的抑制作用,与丝裂霉素组比较差异无统计学意义,羟喜树碱与顺铂对HepA细胞的敏感性较差.
목적 비교소목정여사렬매소、순박、간희수감등약물복강화료대소서간암복수형HepA세포적억제작용,탐토소목정림상복강화료적가행성.방법 복강내접충HepA세포,건립소서간암복수류모형,접충후24 h개시복막강내주사급약,급약결속후동물상규사양,정기측량소서체중,관찰각조동물적생존상태,비교각조동물적평균생존시간.실험중복3차,비교3차실험적T/C치.결과 대조조동물적평균생존시간위15.99～16.33 d;소목정조위36.35～39.81 d;사렬매소조위35.77～40.06 d;간희수감조위20.79～38.47 d;순박조위32.98～41.89 d.종합비교이사렬매소조화소목정조효과교호.결론 소목정복강화료대소서이식성간암HepA세포유현저적억제작용,여사렬매소조비교차이무통계학의의,간희수감여순박대HepA세포적민감성교차.
Objective To compare the inhibitory effects to mice ascitic hepatoma (HepA) among hematoxylin,mitomycin,cisplatin,hydroxycamptothecine and other medicine in celiac chemotherapeutic route,probing into the credibility of hematoxylin in celiac chemotherapy.Methods Mice ascitic HepA model was set up by celiac inoculation of HepA strains.24 h after the inoculation,intraperitoneal administration was done,then raising the mice as routine.Their body weights were measured regularly,living quality observed,mean survival times compared among these groups.Having repeated the above experiment three tines,T/C values obtained in the three experiments were compared one another.Results The awerage survival time of mice of control group (inoculated but no medicine used) was 15.99-16.33 d; that of hematoxylin group was 36.35-39.81 d; that of mitomycin gro.up was 35.77-40.06 d; that of hydroxycamptothecine survived 20.79-38.47 d; and that of cisplatin group was 32.98-41.89 d.A comprehensive comparison showed that mitomycin group and hematoxylin group had better effects.Conclusion Hematoxylin in celiac chemotherapy has an outstanding effect to the mice's transplanted HepA,no significant difference with mitomycin.However,hydroxycamptothecine and cisplatin are not good enough.