CAJ | 학술논문

目的观察胃癌局部免疫反应细胞与胃癌生物学行为的关系。方法对107例有3～8年随访资料的胃癌根治性切除标本作局部免疫细胞反应程度的观察。淋巴-浆细胞反应和嗜酸性白细胞反应用图像分析系统作定量测定，肥大细胞在光镜下以个/mm2作定量计数,然后以均数作界值分为高反应组和低反应组,并分析与临床病理参数的关系。结果患者存活时间、肿瘤浸润深度和淋巴结转移情况在胃癌局部免疫细胞反应的高反应组和低反应组间存在显著差异(P<0.05)。结论胃癌局部免疫细胞反应是宿主重要的抗瘤免疫防御机制。
목적관찰위암국부면역반응세포여위암생물학행위적관계。방법대107례유3～8년수방자료적위암근치성절제표본작국부면역세포반응정도적관찰。림파-장세포반응화기산성백세포반응용도상분석계통작정량측정，비대세포재광경하이개/mm2작정량계수,연후이균수작계치분위고반응조화저반응조,병분석여림상병리삼수적관계。결과환자존활시간、종류침윤심도화림파결전이정황재위암국부면역세포반응적고반응조화저반응조간존재현저차이(P<0.05)。결론위암국부면역세포반응시숙주중요적항류면역방어궤제。
Objective　To study the relationship between the biologic behaviours of gastric carcinoma (GC) and the immune reaction cells of GC tissue. Methods　One hundred and seven radical gastrectomy specimens and 3 to 8 years follow-up data were quantitatively assessed on the reactive degree of lymph-plasma cells and eosinophils with CMIAS image analysis system. Mast cell reaction was accounted in the low power microscopy. Each indicator was divided into two groups, high reaction group and low reaction group, according to the intensity of reactions. Both high reaction and low reaction group were analysed on the base of clinicopathologic parameters. Results　There was a significant difference in the survival time, depth of tumour invasion and lymph node metastasis in GC tissue between high reaction group and low reaction group (P<0.05). Conclusions　Local immune reaction cells plays an important role in the defense mechanism of GC host against the tumour cells invising and spreading.