中国临床康复
中國臨床康複
중국림상강복
CHINESE JOURNAL OF CLINICAL REHABILITATION
2004年
36期
8396-8397
,共2页
赵艳%赵英%张孟玲%段永梅%路秀珍%孙美
趙豔%趙英%張孟玲%段永梅%路秀珍%孫美
조염%조영%장맹령%단영매%로수진%손미
关节炎/中药疗法%中档损伤%中草药%注射剂
關節炎/中藥療法%中檔損傷%中草藥%註射劑
관절염/중약요법%중당손상%중초약%주사제
背景:应用抗骨痛注射液治疗关节肿痛经过对中药的多次筛选及10余年的临床观察,在消除关节肿痛、颈椎病、骨关节病症状及体征方面效果较为突出.为进一步研究抗骨痛对关节肿痛、颈椎病、骨关节病治疗作用的机制,作者做了动物实验观察.目的:探讨中药抗骨痛注射液治疗局部软组织增生、水肿、刺痛或压迫神经的作用机制.设计:随机对照研究.单位:解放军第二○二医院理疗科,上海中医药大学实验动物部.材料:实验于2002-05/2003-01在上海中医药大学实验动物部完成,并由该部提供4月龄健康雌性SD大鼠21只,清洁级,按体质量随机抽样分成3组,即对照组、地塞米松组、抗骨痛组,每组7只大鼠.方法:对照组,腹腔注射生理盐水6mL;地塞米松组,腹腔注射0.08 g/L地塞米松6 mL;抗骨痛组,腹腔注射抗骨痛注射液6 mL,0.5 h后,在3组大鼠右踝关节周围每只注入0.3 mL的尿酸钠(25 g/L)造成关节炎,分别在实验前和实验后10,20 h检测右踝关节的周径.主要观察指标:实验前和实验后10,20 h大鼠右踝关节的周径.结果:3组大鼠右踝关节在尿酸钠的作用下发生了无菌性关节炎,局部肿胀.由于各组在腹腔内注射了不同药物,而使关节肿胀不同.实验后10 h关节肿胀程度比较:对照组、地塞米松组及抗骨痛组的关节周径分别为(57.80±2.26),(31.12±5.11)及(43.86±4.92)mm.地塞米松组、抗骨痛组分别与对照组比较,差异均具有显著性意义(t=12.28,P＜0.01;t=7.56,P＜0.01).实验后20 h踝关节肿胀程度比较:对照组、地塞米松组及抗骨痛组的关节周径分别为(49.86±6.28),(6.82±4.92)及(26.71±5.42)mm.地塞米松组、抗骨痛组分别与对照组比较,差异均具有显著性意义(t=14.27,P＜0.01;t=7.38,P＜0.01).结论:抗骨痛注射液与地塞米松一样,对关节炎性变化和肿胀现象具有良好的消炎、消肿作用.
揹景:應用抗骨痛註射液治療關節腫痛經過對中藥的多次篩選及10餘年的臨床觀察,在消除關節腫痛、頸椎病、骨關節病癥狀及體徵方麵效果較為突齣.為進一步研究抗骨痛對關節腫痛、頸椎病、骨關節病治療作用的機製,作者做瞭動物實驗觀察.目的:探討中藥抗骨痛註射液治療跼部軟組織增生、水腫、刺痛或壓迫神經的作用機製.設計:隨機對照研究.單位:解放軍第二○二醫院理療科,上海中醫藥大學實驗動物部.材料:實驗于2002-05/2003-01在上海中醫藥大學實驗動物部完成,併由該部提供4月齡健康雌性SD大鼠21隻,清潔級,按體質量隨機抽樣分成3組,即對照組、地塞米鬆組、抗骨痛組,每組7隻大鼠.方法:對照組,腹腔註射生理鹽水6mL;地塞米鬆組,腹腔註射0.08 g/L地塞米鬆6 mL;抗骨痛組,腹腔註射抗骨痛註射液6 mL,0.5 h後,在3組大鼠右踝關節週圍每隻註入0.3 mL的尿痠鈉(25 g/L)造成關節炎,分彆在實驗前和實驗後10,20 h檢測右踝關節的週徑.主要觀察指標:實驗前和實驗後10,20 h大鼠右踝關節的週徑.結果:3組大鼠右踝關節在尿痠鈉的作用下髮生瞭無菌性關節炎,跼部腫脹.由于各組在腹腔內註射瞭不同藥物,而使關節腫脹不同.實驗後10 h關節腫脹程度比較:對照組、地塞米鬆組及抗骨痛組的關節週徑分彆為(57.80±2.26),(31.12±5.11)及(43.86±4.92)mm.地塞米鬆組、抗骨痛組分彆與對照組比較,差異均具有顯著性意義(t=12.28,P＜0.01;t=7.56,P＜0.01).實驗後20 h踝關節腫脹程度比較:對照組、地塞米鬆組及抗骨痛組的關節週徑分彆為(49.86±6.28),(6.82±4.92)及(26.71±5.42)mm.地塞米鬆組、抗骨痛組分彆與對照組比較,差異均具有顯著性意義(t=14.27,P＜0.01;t=7.38,P＜0.01).結論:抗骨痛註射液與地塞米鬆一樣,對關節炎性變化和腫脹現象具有良好的消炎、消腫作用.
배경:응용항골통주사액치료관절종통경과대중약적다차사선급10여년적림상관찰,재소제관절종통、경추병、골관절병증상급체정방면효과교위돌출.위진일보연구항골통대관절종통、경추병、골관절병치료작용적궤제,작자주료동물실험관찰.목적:탐토중약항골통주사액치료국부연조직증생、수종、자통혹압박신경적작용궤제.설계:수궤대조연구.단위:해방군제이○이의원리료과,상해중의약대학실험동물부.재료:실험우2002-05/2003-01재상해중의약대학실험동물부완성,병유해부제공4월령건강자성SD대서21지,청길급,안체질량수궤추양분성3조,즉대조조、지새미송조、항골통조,매조7지대서.방법:대조조,복강주사생리염수6mL;지새미송조,복강주사0.08 g/L지새미송6 mL;항골통조,복강주사항골통주사액6 mL,0.5 h후,재3조대서우과관절주위매지주입0.3 mL적뇨산납(25 g/L)조성관절염,분별재실험전화실험후10,20 h검측우과관절적주경.주요관찰지표:실험전화실험후10,20 h대서우과관절적주경.결과:3조대서우과관절재뇨산납적작용하발생료무균성관절염,국부종창.유우각조재복강내주사료불동약물,이사관절종창불동.실험후10 h관절종창정도비교:대조조、지새미송조급항골통조적관절주경분별위(57.80±2.26),(31.12±5.11)급(43.86±4.92)mm.지새미송조、항골통조분별여대조조비교,차이균구유현저성의의(t=12.28,P＜0.01;t=7.56,P＜0.01).실험후20 h과관절종창정도비교:대조조、지새미송조급항골통조적관절주경분별위(49.86±6.28),(6.82±4.92)급(26.71±5.42)mm.지새미송조、항골통조분별여대조조비교,차이균구유현저성의의(t=14.27,P＜0.01;t=7.38,P＜0.01).결론:항골통주사액여지새미송일양,대관절염성변화화종창현상구유량호적소염、소종작용.
BACKGROUND: By several screenings and more than ten-year clinical observation, it is discovered that the outstanding results have been achieved by the treatment of joint swelling and pain with Kanggutong injection (KGT)in the aspects of releasing joint swelling and pain, cervical spondylosis, the symptoms and physical signs of osteoarthropathy. In order to study on the mechanism of KGT on joint swelling and pain, cervical spandylosis and osteoarthropathy, the writers carried on the animal experiment.OBJECTIVE: To probe into the mechanism of KGT injection on the treatment of local soft tissue hyperplasia, edema, pricking pain or neural compression.DESIGN: A randomized controlled study.SETTING: Department of Physiotherapy, the 202 Hospital of Chinese PLA,Department of Experimental Animal, Shanghai University of Traditional Chinese Medicine.PARTICIPANTS: The experiment was accomplished in the Department of Experimental Animal of Shanghai University of Traditional Chinese Medicine from May 2002 to January 2003. The department provided 21 normal female SD rats, aged 4 months, clean grade, which were divided into 3 groups at random, named as control group, dexamethasone(DXM) group and KGT group, 7 rats in each group.INTERVENTIONS: Abdominal injection with physiological saline 6ml was done in control, with DXM 0.08 g/L, 6 mL in DXM group and with KGT 6 mL in KGT group. 0.5 hour later, uric acid sodium 0. 3 mL (25 g/L) was injected peripherally on the right ankle joint of each rat in 3 groups to induce arthritis. The perimeter of the right ankle joint was tested before and 10 and 20 hours after experiment.MAIN OUTCOME MEASURES: The perimeter of the right ankle joint before and 10 and 20 hours after experimentRESULTS: The right ankle joints of rats in the 3 groups were induced aseptic arthritic and local swelling by uric acid sodium. But the severity of swelling was various due to intra-abdominal injection of different medicines. Comparison of joint swelling severity 10 hours after experiment: the joint perimeters in the control, DXM and KGT groups were(57.80 ±2.26), (31.12 ±5.11) and (43.86 ±4. 92) mm respectively. Compared with the control group, the differences in DXM and KGT groups were significant( t = 12.28, P ＜ 0.01; t= 7.56, P ＜ 0. 01 ). Comparison of joint swelling severities 20 hours after experiment: the joint perimeters in the control, DXM and KGT groups were (49.86 ± 6.28), (6.82 ± 4.92) and(26.71 ± 5.42) mm respectively. Compared with the control group, the differences in DXM and KGT groups weresignificant(t= 14. 27, P ＜0.01;t =7.38, P ＜0.01).CONCLUSION: The same as DXM, KGT injection acts on anti-inflammation and anti-swelling for arthritic changes and swelling.
