CAJ | 학술논문

【目的】探讨肺炎、腹泻患儿的维生素A(VA)状况并对其进行分析。【方法】用血清VA值评价60例肺炎、85例腹泻患儿和100名健康儿童的血清VA状况。用相对剂量反应(RDR)深入研究患儿体内VA状况并对其进行多元回归分析。以血清VA＜0.7μmol/L，RDR≥20%为亚临床VA缺乏(SVAD)诊断标准。【结果】肺炎、腹泻患儿的血清VA值分别为(1.0±0.4)μmol/L、(0.7±0.4)μmol/L，明显低于健康儿童(1.9±0.6)μmol/L(P＜0.01)。肺炎、腹泻患儿的RDR均值分别为23%±20%，23%±13%，SVAD检出率分别为43.3%和61.2%(P＜0.05)。肺炎患儿的RDR值和SVAD检出率以小年龄农村、发热组为高(P＜0.05)。腹泻患儿的RDR值和SVAD检出率以小年龄、脱水组为高(P＜0.01)。多元回归分析提示：家居农村发热是肺炎患儿，小年龄、热度高、脱水是腹泻患儿SVAD的影响因素。【结论】肺炎、腹泻患儿的血清VA状况劣于健康儿童。年龄小、家居农村、发热和脱水与其体内VA状况关系较密切。
【목적】탐토폐염、복사환인적유생소A(VA)상황병대기진행분석。【방법】용혈청VA치평개60례폐염、85례복사환인화100명건강인동적혈청VA상황。용상대제량반응(RDR)심입연구환인체내VA상황병대기진행다원회귀분석。이혈청VA＜0.7μmol/L，RDR≥20%위아림상VA결핍(SVAD)진단표준。【결과】폐염、복사환인적혈청VA치분별위(1.0±0.4)μmol/L、(0.7±0.4)μmol/L，명현저우건강인동(1.9±0.6)μmol/L(P＜0.01)。폐염、복사환인적RDR균치분별위23%±20%，23%±13%，SVAD검출솔분별위43.3%화61.2%(P＜0.05)。폐염환인적RDR치화SVAD검출솔이소년령농촌、발열조위고(P＜0.05)。복사환인적RDR치화SVAD검출솔이소년령、탈수조위고(P＜0.01)。다원회귀분석제시：가거농촌발열시폐염환인，소년령、열도고、탈수시복사환인SVAD적영향인소。【결론】폐염、복사환인적혈청VA상황렬우건강인동。년령소、가거농촌、발열화탈수여기체내VA상황관계교밀절。
【Objective】　To explore the body vitamin A(VA) status among children with pneumonia or diarrhea and its risk factors.　【Methods】　Vitamin A status and risk factors are identified by measured the concentration of serum vitamin A and Relative Dose Response(RDR).60 children with pneumonia,85 children with diarrhea and 100 health children were investigated.RDR≥20% or serum VA＜0.70umol is considered as Subclinical Vitamin A Deficiency(SVAD).　【Results】　The result showed that serum VA levels of the cases with pneumonia,diarrhea and health children were(1.0±0.4) umol/L,(0.7±0.4)umol/L and (1.9±0.6)umol/L respectively (F=152.890,P＜0.01).The incidences of SVAD in 3 groups were 28.3%,54.1% and 1.0%,respectively (χ2＝67.381,P＜0.005).Among children with pneumonia and diarrhea,the average values for RDR are 23%±20% and 23%±13%,respectively.The incidence of SVAD among children with diarrhea (61.2%) was significantly higher than those with pneumonia(43.3%)(P＜0.05).Children with diarrhea who were younger,high fever,dehydration had markedly higher RDR and incidence of SVAD(P＜0.01).Among children with pneumonia,those in rural area and fever had higher RDR than their control group(P＜0.05).　【Conclusions】　The incidence of SVAD among children with pneumonia and diarrhea was higher than that in health children.Among children with pneumonia and diarrhea,multiple risk factors needs to be considered together for SVAD.Overall,children who were younger,in rural area,with symptoms such as fever,dehydration,were more susceptible for SVAD.