天津医药
天津醫藥
천진의약
TIANJIN MEDICAL JOURNAL
2010年
3期
180-182
,共3页
袁晓华%刘士莹%曹丽%张蕴
袁曉華%劉士瑩%曹麗%張蘊
원효화%류사형%조려%장온
葡糖耐量试验%颈动脉疾病%超声检查,多普勒%动脉硬化%危险因素%中年人
葡糖耐量試驗%頸動脈疾病%超聲檢查,多普勒%動脈硬化%危險因素%中年人
포당내량시험%경동맥질병%초성검사,다보륵%동맥경화%위험인소%중년인
glucose tolerance test%carotid artery diseases%ultrasonography,doppler%arteriosclerosis risk factors middle aged
目的:探讨影响中老年糖耐量减低(IGT)患者早期动脉硬化(AS)的危险因素.方法:选取中老年IGT患者(IGT组)及正常对照(NGT组)各50例,采用高分辨率多普勒超声检测2组颈动脉内-中膜厚度(IMT)值和肱动脉血流介导的血管扩张功能(FMD),用肱动脉舒张内径的变化率(D%)表示;检测身高、体质量、腰围、臀围、血压,测定空腹(FPG)及糖负荷后2 h血浆血糖(2 hPG)、空腹胰岛素(FINS)、三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、高敏C反应蛋白(hs-CRP)、一氧化氮(NO),并计算体质量指数(BMI)、腰臀比(WHR)、胰岛素抵抗指数(HOMA-IR).分析上述指标与颈动脉IMT的相关性及影响颈动脉IMT的危险因素.结果:IGT组BMI、WHR、2 hPG、TG、LDL-C、hs-CRP、HNS、HOMA-IR和颈动脉IMT均较NGT组增高,但NO及D%较NGT组减低,差别均有统计学意义(P＜0.05或P＜0.01);IGT组颈动脉IMT与年龄、BMI、WHR、2hPG、TC、LDL-C、ks-CRP及HOMA-IR均呈正相关(P＜0.05或P＜0.01),与D%呈负相关(P＜0.01);年龄、WHR、HOMA-IR及D%是颈动脉IMT的影响因素.结论:年龄、中心型肥胖、胰岛素抵抗、内皮功能异常是影响中老年IGT患者发生早期AS的因素.
目的:探討影響中老年糖耐量減低(IGT)患者早期動脈硬化(AS)的危險因素.方法:選取中老年IGT患者(IGT組)及正常對照(NGT組)各50例,採用高分辨率多普勒超聲檢測2組頸動脈內-中膜厚度(IMT)值和肱動脈血流介導的血管擴張功能(FMD),用肱動脈舒張內徑的變化率(D%)錶示;檢測身高、體質量、腰圍、臀圍、血壓,測定空腹(FPG)及糖負荷後2 h血漿血糖(2 hPG)、空腹胰島素(FINS)、三酰甘油(TG)、總膽固醇(TC)、低密度脂蛋白膽固醇(LDL-C)、高密度脂蛋白膽固醇(HDL-C)、高敏C反應蛋白(hs-CRP)、一氧化氮(NO),併計算體質量指數(BMI)、腰臀比(WHR)、胰島素牴抗指數(HOMA-IR).分析上述指標與頸動脈IMT的相關性及影響頸動脈IMT的危險因素.結果:IGT組BMI、WHR、2 hPG、TG、LDL-C、hs-CRP、HNS、HOMA-IR和頸動脈IMT均較NGT組增高,但NO及D%較NGT組減低,差彆均有統計學意義(P＜0.05或P＜0.01);IGT組頸動脈IMT與年齡、BMI、WHR、2hPG、TC、LDL-C、ks-CRP及HOMA-IR均呈正相關(P＜0.05或P＜0.01),與D%呈負相關(P＜0.01);年齡、WHR、HOMA-IR及D%是頸動脈IMT的影響因素.結論:年齡、中心型肥胖、胰島素牴抗、內皮功能異常是影響中老年IGT患者髮生早期AS的因素.
목적:탐토영향중노년당내량감저(IGT)환자조기동맥경화(AS)적위험인소.방법:선취중노년IGT환자(IGT조)급정상대조(NGT조)각50례,채용고분변솔다보륵초성검측2조경동맥내-중막후도(IMT)치화굉동맥혈류개도적혈관확장공능(FMD),용굉동맥서장내경적변화솔(D%)표시;검측신고、체질량、요위、둔위、혈압,측정공복(FPG)급당부하후2 h혈장혈당(2 hPG)、공복이도소(FINS)、삼선감유(TG)、총담고순(TC)、저밀도지단백담고순(LDL-C)、고밀도지단백담고순(HDL-C)、고민C반응단백(hs-CRP)、일양화담(NO),병계산체질량지수(BMI)、요둔비(WHR)、이도소저항지수(HOMA-IR).분석상술지표여경동맥IMT적상관성급영향경동맥IMT적위험인소.결과:IGT조BMI、WHR、2 hPG、TG、LDL-C、hs-CRP、HNS、HOMA-IR화경동맥IMT균교NGT조증고,단NO급D%교NGT조감저,차별균유통계학의의(P＜0.05혹P＜0.01);IGT조경동맥IMT여년령、BMI、WHR、2hPG、TC、LDL-C、ks-CRP급HOMA-IR균정정상관(P＜0.05혹P＜0.01),여D%정부상관(P＜0.01);년령、WHR、HOMA-IR급D%시경동맥IMT적영향인소.결론:년령、중심형비반、이도소저항、내피공능이상시영향중노년IGT환자발생조기AS적인소.
Objective:To determine the risk factor for early stage atherosclerosis in elderly patients with impaired glucose tolerance(IGT).Methods:One hundred patients were divided into 2 groups,experimental group(IGT,n=50)and control group(NGT,n=50).Patients in both groups underwent high-frequency Doppler echocardiography to evaluate intima-media thickness(IMT)of carotid artery and flow-mediated diastolic function(FMD)of brachial artery,which was indicated by diastolic inner diameter changing rate(D %).The values were measured in both groups of including body height,body weight,waist line,hip line,blood pressure,fasting plasma glucose(FPG),two hours plasma glucose(2hPG),fasting insulin(FINS),triglyceride(TG),total cholesterol(TC),low density lipoprotein-cholesterol(LDL-C),high density lipoprotein-cbolesterel(HDL-C),high sensitive C-reactive protein(hs-CRP),nitrogen monoxidum(NO),body mass index(BMl),waist-to-hip ratios(WHR),and insulin resistance index with homeostasis model(HOMA-IR).The association between all of the parameters and IMT,and the risk factors for the carotid artery were analysed in IGT group.Results:The values of BMI,WHR,2hPG,TG,LDL-C,hs-CRP,FINS and IMT of carotid artery were significantly increased in IGT group compared with those of the NGT group.Conversely,NO,HOMA-IR and D% were significantly decreased in IGT group than those of NGT group(P ＜ 0.05 or P ＜ 0.01).There was positive correlation between carotid-IMT and the age,BMI,WHR,2hPG,TC,LDL-C,hs-CRP and HOMA-IR in IGT group(P ＜0.05 or P ＜ 0.01).Inversely,there was negative correlation between carotid-IMT with D% in IGT group(P ＜ 0.01).The risk factors for carotid-IMT were age,WHR,HOMA-IR and D%.Conclusion:Elderly patients with IGT have already had risk factors for early stage atherosclerosis,including age,concentric obesity,insulin resistance,and impaired endothelial function.
