国际生物医学工程杂志
國際生物醫學工程雜誌
국제생물의학공정잡지
INTERNATIONAL JOURNAL OF BIOMEDICAL ENGINEERING
2012年
2期
121-124
,共4页
低密度脂蛋白%高密度脂蛋白%血浆灌流%吸附
低密度脂蛋白%高密度脂蛋白%血漿灌流%吸附
저밀도지단백%고밀도지단백%혈장관류%흡부
Low density lipoprotein%High density lipoprotein%Hemoperfusion%Adsorption
目的 目前,用于降低血液中低密度脂蛋白(LDL)的吸附分离材料尚存在需要改进的地方.HB-H-8树脂在吸附LDL方面尚无应用,本研究对HB-H-8树脂的吸附性能进行了初步评价.方法 首先实验室制备HB-H-8树脂,经过处理后用其对LDL高于正常范围的患者血清标本进行体外动态和静态吸附实验.结果 体外动态吸附结果表明,HB-H-8树脂对LDL的吸附饱和时间为2h,最适吸附温度为恒温37℃,体外静态吸附结果显示HB-H-8树脂对LDL平均吸附率为63.2％,而对高密度脂蛋白(HDL)的平均吸附率为1.9％.结论 HB-H-8树脂对LDL具有良好的特异性吸附性能,有望开发为一种低密度脂蛋白的血液净化医用吸附材料.
目的 目前,用于降低血液中低密度脂蛋白(LDL)的吸附分離材料尚存在需要改進的地方.HB-H-8樹脂在吸附LDL方麵尚無應用,本研究對HB-H-8樹脂的吸附性能進行瞭初步評價.方法 首先實驗室製備HB-H-8樹脂,經過處理後用其對LDL高于正常範圍的患者血清標本進行體外動態和靜態吸附實驗.結果 體外動態吸附結果錶明,HB-H-8樹脂對LDL的吸附飽和時間為2h,最適吸附溫度為恆溫37℃,體外靜態吸附結果顯示HB-H-8樹脂對LDL平均吸附率為63.2％,而對高密度脂蛋白(HDL)的平均吸附率為1.9％.結論 HB-H-8樹脂對LDL具有良好的特異性吸附性能,有望開髮為一種低密度脂蛋白的血液淨化醫用吸附材料.
목적 목전,용우강저혈액중저밀도지단백(LDL)적흡부분리재료상존재수요개진적지방.HB-H-8수지재흡부LDL방면상무응용,본연구대HB-H-8수지적흡부성능진행료초보평개.방법 수선실험실제비HB-H-8수지,경과처리후용기대LDL고우정상범위적환자혈청표본진행체외동태화정태흡부실험.결과 체외동태흡부결과표명,HB-H-8수지대LDL적흡부포화시간위2h,최괄흡부온도위항온37℃,체외정태흡부결과현시HB-H-8수지대LDL평균흡부솔위63.2％,이대고밀도지단백(HDL)적평균흡부솔위1.9％.결론 HB-H-8수지대LDL구유량호적특이성흡부성능,유망개발위일충저밀도지단백적혈액정화의용흡부재료.
Objective Currently,adsorption materials applied to remove low density lipoprotein (LDL) still remain defects.HB-H-8 resin has not been put in use in removing LDL.This study focused on primary evaluation of adsorption capability of HB-H-8 resin.Methods HB-H-8 resin was used in the adsorption of LDL of patient that was higher than the normal range of blood sample in dynamic test and static test in vitro.Results The time of adsorption saturation was two hours,and the optimum temperature was 37℃.The results of adsorption in vitro showed that the average adsorption rates of LDL and high density lipoprotein (HDL) were 63.2％ and 1.9％,respectively.Conclusion HB-H-8 resin has LDL higher adsorption capability,thus made it to be a potential blood purification material for the removal of LDL.
