中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2008年
27期
1-4
,共4页
肝肿瘤%胰岛素样生长因子Ⅱ%抗原,肿瘤相关,碳水化合物
肝腫瘤%胰島素樣生長因子Ⅱ%抗原,腫瘤相關,碳水化閤物
간종류%이도소양생장인자Ⅱ%항원,종류상관,탄수화합물
Liver neoplasms%Insulin-like growth factor Ⅱ%Antigens,tumor-associated,carbohydrate
目的 探讨原发性肝癌患者介入合并无水乙醇注射治疗前后血清胰岛素样生长因子(IGF)-Ⅱ、CA19-9和AFP的变化及临床意义.方法 应用放射免疫分析法对57例原发性肝癌患者(病例组)进行了血清IGF-Ⅱ、CA19-9和AFP含量检测,并设对照组(42例)进行比较.结果 病例组介入合并无水乙醇注射治疗前血清IGF-Ⅱ、CA19-9和AFP显著高于对照组(P＜0.01),病例组介入合并无水乙醇注射治疗后1个月血清IGF-Ⅱ、CA19-9和AFT皆已接近正常,治疗后6个月再测,未复发者仍然属于正常水平,而复发者又恢复至介入合并无水乙醇注射治疗前水平.结论 测定原发性肝癌患者血清IGF-Ⅱ、CA19-9和AFP的变化对患者治疗效果和预后判定均具有重要的临床价值.
目的 探討原髮性肝癌患者介入閤併無水乙醇註射治療前後血清胰島素樣生長因子(IGF)-Ⅱ、CA19-9和AFP的變化及臨床意義.方法 應用放射免疫分析法對57例原髮性肝癌患者(病例組)進行瞭血清IGF-Ⅱ、CA19-9和AFP含量檢測,併設對照組(42例)進行比較.結果 病例組介入閤併無水乙醇註射治療前血清IGF-Ⅱ、CA19-9和AFP顯著高于對照組(P＜0.01),病例組介入閤併無水乙醇註射治療後1箇月血清IGF-Ⅱ、CA19-9和AFT皆已接近正常,治療後6箇月再測,未複髮者仍然屬于正常水平,而複髮者又恢複至介入閤併無水乙醇註射治療前水平.結論 測定原髮性肝癌患者血清IGF-Ⅱ、CA19-9和AFP的變化對患者治療效果和預後判定均具有重要的臨床價值.
목적 탐토원발성간암환자개입합병무수을순주사치료전후혈청이도소양생장인자(IGF)-Ⅱ、CA19-9화AFP적변화급림상의의.방법 응용방사면역분석법대57례원발성간암환자(병례조)진행료혈청IGF-Ⅱ、CA19-9화AFP함량검측,병설대조조(42례)진행비교.결과 병례조개입합병무수을순주사치료전혈청IGF-Ⅱ、CA19-9화AFP현저고우대조조(P＜0.01),병례조개입합병무수을순주사치료후1개월혈청IGF-Ⅱ、CA19-9화AFT개이접근정상,치료후6개월재측,미복발자잉연속우정상수평,이복발자우회복지개입합병무수을순주사치료전수평.결론 측정원발성간암환자혈청IGF-Ⅱ、CA19-9화AFP적변화대환자치료효과화예후판정균구유중요적림상개치.
Objective To investigate the clinical significance of changes of serum insulin-like growth factor-Ⅱ(IGF-Ⅱ),carbohydrate antigen 19-9(CA19-9)and alpha fetoprotein(AFP)levels after intervention and percutaneous ethanol injection therapy in patients with primary hepatic cancer.Methods Serum levels of IGF-Ⅱ,CA19-9 and AFP(with RIA)were repeatedly determined in 57 patients with primary hepatic cancer before intervention therapy,1 month after intervention and percutaneous ethanol injection therapy and 6 months after intervention and percutaneous ethanol injection therapy as well as in 42 controls.Results Before intervention therapy,serum leveh of IGF-Ⅱ,CA19-9 and AFP in the patients were significantly higher than those in the controls(P＜0.01).One month after intervention and percutaneous ethanol injection therapy,all the serum levels were near to normal.Six months later,the levels in the patients without recurrence remained normal.However,the levels in the 10 patients with recurrence returned to those before intervention therapy again.Conclusion Changes of serum IGF-Ⅱ,CA19-9 and AFP levels are closely related to the tumor burden and may reflect the presence of recurrence.
