CAJ | 학술논문

目的探讨有胎儿生长受限(FGR)高危因素的孕妇孕早期使用低分子肝素预防FGR的临床疗效.方法 100例孕妇分为观察组60例、对照组40组,均给予维生素E、叶酸每天口服1次,持续至妊娠12周.观察组若D-二聚体检查结果正常则加用低分子肝素5000 u每天皮下注射1次,持续至妊娠12周.D-二聚体检查结果异常者调整低分子肝素用量使其结果降至正常.比较两组妊娠结局.结果观察组分娩孕周、新生儿出生体质量、胎盘重量显著高于对照组(t =4.55、2.79、11.91,均P＜0.05),FGR、羊水过少、胎儿窘迫、妊娠期高血压疾病的发生率显著低于对照组(x2=6.50、20.55、7.87、3.76,均P＜0.05)；两组宫内死胎、新生儿窒息、围产儿死亡的发生率差异均无统计学意义(均P＞0.05).结论有FGR高危因素的孕妇孕早期使用低分子肝素可有效预防和改善FGR,改善妊娠不良结局.
목적 탐토유태인생장수한(FGR)고위인소적잉부잉조기사용저분자간소예방FGR적림상료효.방법 100례잉부분위관찰조60례、대조조40조,균급여유생소E、협산매천구복1차,지속지임신12주.관찰조약D-이취체검사결과정상칙가용저분자간소5000 u매천피하주사1차,지속지임신12주.D-이취체검사결과이상자조정저분자간소용량사기결과강지정상.비교량조임신결국.결과 관찰조분면잉주、신생인출생체질량、태반중량현저고우대조조(t =4.55、2.79、11.91,균P＜0.05),FGR、양수과소、태인군박、임신기고혈압질병적발생솔현저저우대조조(x2=6.50、20.55、7.87、3.76,균P＜0.05)；량조궁내사태、신생인질식、위산인사망적발생솔차이균무통계학의의(균P＞0.05).결론 유FGR고위인소적잉부잉조기사용저분자간소가유효예방화개선FGR,개선임신불량결국.
Objective To study the clinical effect of low molecular weight heparin on fetal growth restriction (FGR) prevention in early pregnancy.Methods 100 pregnant women had been employed in our study,they were divided into two groups,observation( n =60) and control( n =40) group.Both groups were given the natural vitamin E 0.1g,and folie acid 0.4mg daily oral administration,continuing to 12 weeks of gestation.5000 u of subcutaneous dalteparin sodium was added to pregnant women with notmal level of D-dimer in the observation group until 12 weeks of pregnancy,while the dose of Fragmin was adjusted in pregnant women with abnormal level of D-dimer until retuned to normal level.The pregnacy outcome of two groups were compared.Results The gestational age,birth weight,placental weight of the obseruation group was signiticantly higher than thal of the control group ( t =4.55,2.79,11.91,all P ＜ 0.05 ),while FGR,oligohydramnies,fetal distress and the incidence of hypertensive disorters of the obseruation group were significantly lower than that of control group ( x2 =6.50,20.55,7.87,3.76,all P ＜ 0.05 ) ; Compared to the control group,the observation group didn't have higher incidence of intrauterine fetal death,neonatal asphyxia and perinatal death ( P ＞ 0.05).Conclusion Low molecular weight heparin using in early pregnancy was effective in preventing FGR in pregnant women with FGR risk factors.