中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2011年
24期
3330-3331
,共2页
冯俐平%李景平%吴利玲%王欢华%陈梅%高艳明
馮俐平%李景平%吳利玲%王歡華%陳梅%高豔明
풍리평%리경평%오리령%왕환화%진매%고염명
妊娠期高血压疾病%肿瘤坏死因子α%白细胞介素6
妊娠期高血壓疾病%腫瘤壞死因子α%白細胞介素6
임신기고혈압질병%종류배사인자α%백세포개소6
Hypertensive disorders in pregnancy%TNF-α%IL-6
目的 观察妊娠期高血压疾病(HDIP)患者血清肿瘤坏死因子α(TNF-α)和白细胞介素6(IL-6)水平的变化,探讨其在HDIP发病中的意义.方法 测定30例HDIP(11例妊娠期高血压、11例轻度子痫前期、8例重度子痫前期)和18例健康孕妇的血清TNF-α和IL-6水平.结果 HDIP患者血清TNF-α水平分别为(1.88±0.48)μg/L、(2.32±0.40) μg/L、(2.35±0.42) μg/L,血清IL-6水平分别是(99.54±31.62)ng/L、( 120.53±26.42) ng/L、( 140.83±22.13) ng/L,健康孕妇血清TNF-α水平为(1.63±0.32)μg/L,血清IL-6水平为(95.82±30.65) ng/L,组间差异均有统计学意义(均P＜0.05).结论 HDIP患者血清TNF-α和IL-6水平明显增高,血管内皮细胞损伤在HDIP的发生发展过程中起到重要作用.
目的 觀察妊娠期高血壓疾病(HDIP)患者血清腫瘤壞死因子α(TNF-α)和白細胞介素6(IL-6)水平的變化,探討其在HDIP髮病中的意義.方法 測定30例HDIP(11例妊娠期高血壓、11例輕度子癇前期、8例重度子癇前期)和18例健康孕婦的血清TNF-α和IL-6水平.結果 HDIP患者血清TNF-α水平分彆為(1.88±0.48)μg/L、(2.32±0.40) μg/L、(2.35±0.42) μg/L,血清IL-6水平分彆是(99.54±31.62)ng/L、( 120.53±26.42) ng/L、( 140.83±22.13) ng/L,健康孕婦血清TNF-α水平為(1.63±0.32)μg/L,血清IL-6水平為(95.82±30.65) ng/L,組間差異均有統計學意義(均P＜0.05).結論 HDIP患者血清TNF-α和IL-6水平明顯增高,血管內皮細胞損傷在HDIP的髮生髮展過程中起到重要作用.
목적 관찰임신기고혈압질병(HDIP)환자혈청종류배사인자α(TNF-α)화백세포개소6(IL-6)수평적변화,탐토기재HDIP발병중적의의.방법 측정30례HDIP(11례임신기고혈압、11례경도자간전기、8례중도자간전기)화18례건강잉부적혈청TNF-α화IL-6수평.결과 HDIP환자혈청TNF-α수평분별위(1.88±0.48)μg/L、(2.32±0.40) μg/L、(2.35±0.42) μg/L,혈청IL-6수평분별시(99.54±31.62)ng/L、( 120.53±26.42) ng/L、( 140.83±22.13) ng/L,건강잉부혈청TNF-α수평위(1.63±0.32)μg/L,혈청IL-6수평위(95.82±30.65) ng/L,조간차이균유통계학의의(균P＜0.05).결론 HDIP환자혈청TNF-α화IL-6수평명현증고,혈관내피세포손상재HDIP적발생발전과정중기도중요작용.
Objective To observe the changes of the levels of serum TNF-α and IL-6 in patients with hypertensive disorders in pregnancy(HDIP),to explore the significance of serum TNF-α and IL-6 in HDIP.Methods The levels of serum TNF-α and IL-6 in 30 patients with HDIP( 11 cases with gestational hypertension,11 casses with mild preeclampsia,8 cases with severe preeclampsia) and 18 healthy pregnant women were detected.Results The levels of serum TNF-α in HDIP were( 1.88 ±0.48) μg/L,(2.32 ±0.40) μg/L and(2.35 ± 0.42) μg/L,The levels of serum IL-6 of HDIP were (99.54 ± 31.62) ng/L,( 120.53 ± 26.42)ng/L,( 140.83 ± 22.13 ) ng/L respectively,the serum levels of TNF-α and IL-6 in healthy pregnant women were( 1.63 ± 0.32)μg/L and(95.82 ± 30.65 )ng/L,there was significant difference among them ( all P ＜ 0.05 ).Conclusion The serum levels of TNF-α and IL-6 in HDIP were higer than those in healthy pregnant women,and vascular endothelium cell injury should play an important role in the pathogenesis and development of HDIP.
