CAJ | 학술논문

目的观察老年脑梗死患者血浆同型半胱氨酸( Hcy)和超敏C反应蛋白(hs-CRP)的水平与神经功能缺损程度即美国国立卫生研究院卒中量表(NIHSS)评分的相关性,并探讨其临床意义.方法应用循环酶法和免疫透射比浊法检测116例老年脑梗死患者血浆Hcy和hs-CRP水平,并与100例健康对照者比较.根据NIHSS评分,将脑梗死组分为轻、中、重度3组,各组之间进行比较.结果老年脑梗死组血浆Hcy、hs-CRP水平明显高于健康对照组(t =6.97、14.96,P＜0.01),脑梗死不同临床分型组间血浆Hcy、hs-CRP水平两两比较差异有统计学意义(F=23.49、28.19,P＜0.05),脑梗死患者血浆Hcy、hs-CRP水平与NIHSS评分呈正相关(r=0.54、0.58,P＜0.05).结论血浆Hcy、hs-CRP水平与脑梗死的发生及病情的严重程度密切相关,动态监测血浆Hcy、hs-CRP水平对脑梗死的预测和疗效观察具有积极的临床意义.
목적 관찰노년뇌경사환자혈장동형반광안산( Hcy)화초민C반응단백(hs-CRP)적수평여신경공능결손정도즉미국국립위생연구원졸중량표(NIHSS)평분적상관성,병탐토기림상의의.방법 응용순배매법화면역투사비탁법검측116례노년뇌경사환자혈장Hcy화hs-CRP수평,병여100례건강대조자비교.근거NIHSS평분,장뇌경사조분위경、중、중도3조,각조지간진행비교.결과 노년뇌경사조혈장Hcy、hs-CRP수평명현고우건강대조조(t =6.97、14.96,P＜0.01),뇌경사불동림상분형조간혈장Hcy、hs-CRP수평량량비교차이유통계학의의(F=23.49、28.19,P＜0.05),뇌경사환자혈장Hcy、hs-CRP수평여NIHSS평분정정상관(r=0.54、0.58,P＜0.05).결론 혈장Hcy、hs-CRP수평여뇌경사적발생급병정적엄중정도밀절상관,동태감측혈장Hcy、hs-CRP수평대뇌경사적예측화료효관찰구유적겁적림상의의.
Objective To observe the serum levels of homocysteine (Hcy) and hypersensitivity C-reactive protein(hs-CRP) in elderly patients with cerebral infarction and to investigate their relationship and clinical significance by National Institutes of Health Stroke Scale (NIHSS).Methods The serum levels of Hcy and hs-CRP were by enzymatic cycling method and scattering turbidimetry in the elderly patients ( 116 cases with cerebral infarction and 100 cases of healthy control).Those 116 cases with cerebral infarction were divided into three groups by the degree of NIHSS.The three groups were compared with each other.Results The levels of serum Hcy and hs-CRP in elderly patients with cerebral infarction were significantly higher than that of healthy control group ( t =6.97,P ＜0.01 ; t =14.96,P ＜0.01 ).There has significant difference among those three groups with cerebral infarction by comparing with each other( F =23.49,P ＜0.05; F =28.19,P ＜0.05).A positive correlation was found between Hcy and degree of NIHSS( r=0.54,P ＜0.05),and between hs-CRPand degree of NIHSS( r =0.58,P ＜0.05).Conclusions Serum levels of Hcy and hs-CRP are correlated with the occurrence of cerebral infarction and its severity.There has positive clinical significance to evaluate the effect of cerebral infarction by measuring the serum levels of Hcy and hs-CRP dynamic.