CAJ | 학술논문

目的观察糖尿病性黄斑水肿(DME)的光学相干断层扫描(OCT)临床特征,并探讨其与视功能改变的相关性.方法 40例49眼DME患者(DME组)及31例31眼无DME患者(对照组)分别应用OCT进行黄斑厚度定量分析,同时采用图形视觉诱发电位(P-VEP)及黄斑10°视野平均缺损(MD)指数检查视功能,根据DME组有无合并增生型糖尿病视网膜病变分为A组(非增生型糖尿病视网膜病变+DME,30眼)和B组(增生型糖尿病视网膜病变+DME,19眼).结果 DMEOCT图像定量分析发现,DME组黄斑厚度[(299.25±63.87)μm]较对照组[(204.35±37.94)μm]增厚,且视力、MD指数受损更为严重,其差异有统计学意义(P＜0.05).A组与B组的黄斑厚度、视力、MD指数比较差异均无统计学意义(P＞0.05);OCT黄斑厚度与视力存在线性负相关(r=-0.437,P＜0.05);OCT黄斑厚度与MD指数存在线性正相关(r=0.441,P＜0.05).结论 OCT为评估DME的发生、发展及疗效判断提供了一种有效、客观的检测手段,随着黄斑厚度的增加,视功能指标中视力下降、黄斑10°视野受损程度加重.
목적 관찰당뇨병성황반수종(DME)적광학상간단층소묘(OCT)림상특정,병탐토기여시공능개변적상관성.방법 40례49안DME환자(DME조)급31례31안무DME환자(대조조)분별응용OCT진행황반후도정량분석,동시채용도형시각유발전위(P-VEP)급황반10°시야평균결손(MD)지수검사시공능,근거DME조유무합병증생형당뇨병시망막병변분위A조(비증생형당뇨병시망막병변+DME,30안)화B조(증생형당뇨병시망막병변+DME,19안).결과 DMEOCT도상정량분석발현,DME조황반후도[(299.25±63.87)μm]교대조조[(204.35±37.94)μm]증후,차시력、MD지수수손경위엄중,기차이유통계학의의(P＜0.05).A조여B조적황반후도、시력、MD지수비교차이균무통계학의의(P＞0.05);OCT황반후도여시력존재선성부상관(r=-0.437,P＜0.05);OCT황반후도여MD지수존재선성정상관(r=0.441,P＜0.05).결론 OCT위평고DME적발생、발전급료효판단제공료일충유효、객관적검측수단,수착황반후도적증가,시공능지표중시력하강、황반10°시야수손정도가중.
Objective To explore the clinical features of diabetic macular edema (DME) with optical coherence tomography (OCT) and correlation with visual function. Methods Forty-nine eyes from 40 patients with DME (DME group) and 31 eyes from 31 patients without DME (control group) were examined with OCT,pattern reversal visual evoked potentials (P-VEP),macular perimetry. According to proliferative diabetic retinopathy (PDR), 49 eyes with DME were divided into group A (without PDR, 30eyes) and group B (with PDR, 19 eyes). Results The retinal macular thickness of central fovea in DME group [(299.25±63.87)μm] was more than that in contol group [(204.35 ± 37.94)μm], visual acuity and macular visual field in DME group were significantly different than those in control group, respectively (P ＜ 0.05). The retinal macular thickness of central fovea,visual acuity and visual field were no significant differences between group A and group B (P＞0.05). OCT macular thickness and visual correlation coefficient was -0.437(P＜ 0.05 ); OCT macular thickness and mean defect correlation coefficient was 0.441(P ＜ 0.05). Conclusions OCT can provide a useful tool for monitoring the occurrence and development of DME, can assess the response to treatment. With increasing of the macular retinal thickness, the visual acuity and macular visual field of visual function are more damaged.