CAJ | 학술논문

［目的］研究车间空气中尿素的国家卫生标准。［方法］现场接触工人的职业流行病学调查。尿素的急性及慢性毒性试验。收集国内外有关资料。［结果］尿素的大鼠经口LD50为8 471 mg/kg。大鼠吸入慢性阈浓度为(45.9±9.8)mg/m3。车间空气中尿素浓度在10 mg/m3，未发现接触工人有中毒症状。［结论］建议车间空气中尿素的最高容许浓度为10 mg/m3，其时间加权平均容许浓度为5 mg/m3。
［목적］연구차간공기중뇨소적국가위생표준。［방법］현장접촉공인적직업류행병학조사。뇨소적급성급만성독성시험。수집국내외유관자료。［결과］뇨소적대서경구LD50위8 471 mg/kg。대서흡입만성역농도위(45.9±9.8)mg/m3。차간공기중뇨소농도재10 mg/m3，미발현접촉공인유중독증상。［결론］건의차간공기중뇨소적최고용허농도위10 mg/m3，기시간가권평균용허농도위5 mg/m3。
［Objective］ To establish national health standard for urea in the air of workplace. ［Methods］ Occupational epidemiological investigation and sudies on the acute and chronic toxicity of urea were conducted. The available materials concerning standard setting were collected. ［Results］ LD50 for urea by intragastric administration is 8 471 mg/kg in rats. The threshold of chronic toxic effect in rats is (45.9±9.8)mg/m3. The results of determination showed that the concentrations of urea in the air of workplace were below 10 mg/m3. The adverse effects of urea in exposed workers were not found. ［Concentration］ The maximum allowable concentration(MAC) and the time-weighted average allowable concentration(TWA-AC) have been recommended 10 mg/m3,respectively.