CAJ | 학술논문

目的　通过观察外源性透明质酸(HA)对兔耳创面愈合前后胶原代谢的影响，探讨透明质酸抑制瘢痕增生的机理。方法　18只日本大耳白兔，建立兔耳创伤愈合模型后，随机分成2％HA治疗组（A组），1％HA治疗组（B组）和生理盐水对照组（C组）。术后第3、7、10、14、18天取标本匀浆后测定羟脯氨酸（HPr）含量，将数据进行统计学处理。结果　A、B两组羟脯氨酸含量明显低于C组（P＜0.01），A、B两组间也有统计学差异（P＜0.05）。结论　HA能够抑制成纤维细胞合成胶原，其作用有剂量依赖性。
목적　통과관찰외원성투명질산(HA)대토이창면유합전후효원대사적영향，탐토투명질산억제반흔증생적궤리。방법　18지일본대이백토，건립토이창상유합모형후，수궤분성2％HA치료조（A조），1％HA치료조（B조）화생리염수대조조（C조）。술후제3、7、10、14、18천취표본균장후측정간포안산（HPr）함량，장수거진행통계학처리。결과　A、B량조간포안산함량명현저우C조（P＜0.01），A、B량조간야유통계학차이（P＜0.05）。결론　HA능구억제성섬유세포합성효원，기작용유제량의뢰성。
Objective　By detecting the influence of hydroxyproline on collagen metabolism of wound healing of rabbit ear to investigate the inhibition effect of hyaluronic acid on scar proliferation. Methods　Wound healing model were made on the ears of 18 rabbits. They were randomly divided into 2%HA treated-group(group A), 1%HA treated-group(group B) and normal saline treated-group(group C). The wound area skin was obtained at different days after operation. Tissue hydroxyproline was detected. Data was analyzed statisticaly. Results　The hydroxyproline content in group A and B were lower than group C (P＜0.01). The difference between group A and B was also prominent (P＜0.05). Conclusion　Hyaluronic acid can inhibit the collagen synthesis. The dependence relationship between effect and dosage is notable.