检验医学
檢驗醫學
검험의학
LABORATORY MEDICINE
2010年
2期
89-91
,共3页
妊娠相关血浆蛋白A%高敏C反应蛋白%急性冠状动脉综合征
妊娠相關血漿蛋白A%高敏C反應蛋白%急性冠狀動脈綜閤徵
임신상관혈장단백A%고민C반응단백%급성관상동맥종합정
Pregnancy-associated plasma protein A%High sensitive C reactive protein%Acute coronary syndrome
目的 探讨急性冠状动脉综合征(ACS)患者血清妊娠相关血浆蛋白A (PAPP-A) 、高敏C反应蛋白(hs-CRP)的变化及临床意义.方法 采用时间分辨免疫荧光分析法检测30例急性心肌梗死(AMI)患者、21例不稳定心绞痛(UAP)患者、25例稳定性心绞痛(SAP)患者和20名正常对照者血清PAPP-A,同时用乳胶增强比浊法检测血清hs-CRP.结果 SAP组血清PAPP-A水平与正常对照组比较无差异(P>0.05);UAP组和AMI组血清PAPP-A水平均明显高于正常对照组和SAP组(P均<0.01),但UAP组血清PAPP-A水平与AMI组比较无差异.SAP组血清hs-CRP水平明显高于正常对照组(P<0.05);UAP组明显高于正常对照组和SAP组(P<0.01),但低于AMI组(P<0.01).ACS组血清PAPP-A水平与血清hs-CRP水平呈正相关(r=0.53,P<0.01).结论 ACS患者血清PAPP-A与hs-CRP水平均明显升高,且hs-CRP与PAPP-A之间存在明显相关性.PAPP-A水平升高可能与动脉粥样硬化斑块的不稳定性有关,提示可作为识别ACS的早期血清学标志物.
目的 探討急性冠狀動脈綜閤徵(ACS)患者血清妊娠相關血漿蛋白A (PAPP-A) 、高敏C反應蛋白(hs-CRP)的變化及臨床意義.方法 採用時間分辨免疫熒光分析法檢測30例急性心肌梗死(AMI)患者、21例不穩定心絞痛(UAP)患者、25例穩定性心絞痛(SAP)患者和20名正常對照者血清PAPP-A,同時用乳膠增彊比濁法檢測血清hs-CRP.結果 SAP組血清PAPP-A水平與正常對照組比較無差異(P>0.05);UAP組和AMI組血清PAPP-A水平均明顯高于正常對照組和SAP組(P均<0.01),但UAP組血清PAPP-A水平與AMI組比較無差異.SAP組血清hs-CRP水平明顯高于正常對照組(P<0.05);UAP組明顯高于正常對照組和SAP組(P<0.01),但低于AMI組(P<0.01).ACS組血清PAPP-A水平與血清hs-CRP水平呈正相關(r=0.53,P<0.01).結論 ACS患者血清PAPP-A與hs-CRP水平均明顯升高,且hs-CRP與PAPP-A之間存在明顯相關性.PAPP-A水平升高可能與動脈粥樣硬化斑塊的不穩定性有關,提示可作為識彆ACS的早期血清學標誌物.
목적 탐토급성관상동맥종합정(ACS)환자혈청임신상관혈장단백A (PAPP-A) 、고민C반응단백(hs-CRP)적변화급림상의의.방법 채용시간분변면역형광분석법검측30례급성심기경사(AMI)환자、21례불은정심교통(UAP)환자、25례은정성심교통(SAP)환자화20명정상대조자혈청PAPP-A,동시용유효증강비탁법검측혈청hs-CRP.결과 SAP조혈청PAPP-A수평여정상대조조비교무차이(P>0.05);UAP조화AMI조혈청PAPP-A수평균명현고우정상대조조화SAP조(P균<0.01),단UAP조혈청PAPP-A수평여AMI조비교무차이.SAP조혈청hs-CRP수평명현고우정상대조조(P<0.05);UAP조명현고우정상대조조화SAP조(P<0.01),단저우AMI조(P<0.01).ACS조혈청PAPP-A수평여혈청hs-CRP수평정정상관(r=0.53,P<0.01).결론 ACS환자혈청PAPP-A여hs-CRP수평균명현승고,차hs-CRP여PAPP-A지간존재명현상관성.PAPP-A수평승고가능여동맥죽양경화반괴적불은정성유관,제시가작위식별ACS적조기혈청학표지물.
Objective To investigate the changes and the clinical significance of serum pregnancy-associated plasma protein A(PAPP-A)and high sensitive C reactive protein (hs-CRP) in patients with acute coronary syndrome(ACS). Methods The serum levels of PAPP-A in 30 acute myocardial infarction(AMI)patients,21 unstable angina pectoris (UAP) patients,25 stable angina pectoris (SAP) patients and 20 healthy controls were determined by time-resolved fluoroimmunoassay(TRFIA); the levels of hs-CRP were determined by immune enhancement nephelometry simultaneously. Results The levels of PAPP-A in UAP patients and AMI patients were significantly higher than those in SAP patients and healthy controls(P<0.01), while there was no statistically significant difference between UAP patients and AMI patients or between SAP patients and healthy controls. The levels of hs-CRP in SAP patients were significantly higher than those in healthy controls (P<0.05); the levels of hs-CRP in UAP patients were significantly higher than those in healthy controls and SAP patients (P<0.01), but were lower than those in AMI patients (P<0.01). The levels of PAPP-A in patients with ACS were positively correlated with the levels of hs-CRP (r=0.53, P<0.01). Conclusions The serum levels of PAPP-A and hs-CRP in patients with ACS significantly increase and are positively correlated. The PAPP-A levels′ increasing may be associated with unstable plaque and may become a new candidate marker for early diagnosis of ACS.
