CAJ | 학술논문

川崎病是以全身血管炎为主要病变的急性发热出疹性疾病,其诊断主要依靠临床表现是否符合诊断标准及排除类似疾病,缺乏特异性的诊断手段.近年来,血浆脑利钠肽(BNP)在诊断川崎病中的价值逐渐被人们所重视.研究发现川崎病患儿血浆N末端脑利钠肽原(NT-proBNP)水平在急性期显著升高,具有一定的特异性和敏感性,其升高原因可能与局部心肌炎症、细胞因子及左室舒张功能有关.该文就川崎病患儿急性期血浆NT-proBNP水平升高机制的研究进展作一综述.
천기병시이전신혈관염위주요병변적급성발열출진성질병,기진단주요의고림상표현시부부합진단표준급배제유사질병,결핍특이성적진단수단.근년래,혈장뇌리납태(BNP)재진단천기병중적개치축점피인문소중시.연구발현천기병환인혈장N말단뇌리납태원(NT-proBNP)수평재급성기현저승고,구유일정적특이성화민감성,기승고원인가능여국부심기염증、세포인자급좌실서장공능유관.해문취천기병환인급성기혈장NT-proBNP수평승고궤제적연구진전작일종술.
Kawasaki disease ( KD) is an acute febrile systemic vasculitic syndrome. Since there is no specific diagnostic test for KD, the diagnosis is mainly based on the clinical menifetations according to the criterias and excluding of other diseases. Recently the value of plasma brain natriuretic peptide ( BNP) in the diagnosis of KD has been paid more attention gradually. The plasma NT-proBNP level is significantly elevated in KD patients in the acute phase. It is of some specificity and sensitivity, and it may due to the local myocardial inflammation, cytokines and diastolic function of left ventricular. This review summarizes the mechanisms by which the elevated levels of plasma NT-proBNP occur in the acute phase of KD.