中华劳动卫生职业病杂志
中華勞動衛生職業病雜誌
중화노동위생직업병잡지
CHINESE JOURNAL OF INDUSTRIAL HYGIENE AND OCCUPATIONAL DISEASES
2011年
6期
440-442
,共3页
赖登攀%王建峰%姚菊平%王一芬%陈国琴
賴登攀%王建峰%姚菊平%王一芬%陳國琴
뢰등반%왕건봉%요국평%왕일분%진국금
血液灌流%急性甲胺磷中毒
血液灌流%急性甲胺燐中毒
혈액관류%급성갑알린중독
hemoperfusion(HP)%acute methamidophos poisoning
目的 探讨血液灌流(HP)对甲胺磷中毒患者体内毒物的清除效果.方法 在综合治疗的基础上,对15例重度急性甲胺磷中毒患者予以HP治疗,在HP前,HP开始后5、15、30、45、60 min及HP结束时(120 min)共7个时间点分别采集患者外周静脉血5 ml,测定血清中甲胺磷浓度及血清胆碱酯酶活力,并测定HP后灌流器吸附的甲胺磷含量.结果 15例患者存活12例,死亡3例.55例中毒患者HP前血胆碱酯酶活力为(662.60±632.05)IU/L,HP后血胆碱酯酶活力为(2577.52±920.38)IU/L,灌流前后血胆碱酯酶活力的差异有统计学意义(P<0.01).HP治疗后第45、60、120 min时患者血中甲胺磷浓度分别为(851±672)、(680±529)、(587±520)μg/ml,明显低于HP前(1659±1105)μg/ml,差异有统计学意义(P<0.01).灌流器吸附甲胺磷含量阳性.结论 HP可以明显降低甲胺磷中毒患者血清中毒物浓度,实验方法直接证明了临床应用HP的碳肾确能吸附甲胺磷.
目的 探討血液灌流(HP)對甲胺燐中毒患者體內毒物的清除效果.方法 在綜閤治療的基礎上,對15例重度急性甲胺燐中毒患者予以HP治療,在HP前,HP開始後5、15、30、45、60 min及HP結束時(120 min)共7箇時間點分彆採集患者外週靜脈血5 ml,測定血清中甲胺燐濃度及血清膽堿酯酶活力,併測定HP後灌流器吸附的甲胺燐含量.結果 15例患者存活12例,死亡3例.55例中毒患者HP前血膽堿酯酶活力為(662.60±632.05)IU/L,HP後血膽堿酯酶活力為(2577.52±920.38)IU/L,灌流前後血膽堿酯酶活力的差異有統計學意義(P<0.01).HP治療後第45、60、120 min時患者血中甲胺燐濃度分彆為(851±672)、(680±529)、(587±520)μg/ml,明顯低于HP前(1659±1105)μg/ml,差異有統計學意義(P<0.01).灌流器吸附甲胺燐含量暘性.結論 HP可以明顯降低甲胺燐中毒患者血清中毒物濃度,實驗方法直接證明瞭臨床應用HP的碳腎確能吸附甲胺燐.
목적 탐토혈액관류(HP)대갑알린중독환자체내독물적청제효과.방법 재종합치료적기출상,대15례중도급성갑알린중독환자여이HP치료,재HP전,HP개시후5、15、30、45、60 min급HP결속시(120 min)공7개시간점분별채집환자외주정맥혈5 ml,측정혈청중갑알린농도급혈청담감지매활력,병측정HP후관류기흡부적갑알린함량.결과 15례환자존활12례,사망3례.55례중독환자HP전혈담감지매활력위(662.60±632.05)IU/L,HP후혈담감지매활력위(2577.52±920.38)IU/L,관류전후혈담감지매활력적차이유통계학의의(P<0.01).HP치료후제45、60、120 min시환자혈중갑알린농도분별위(851±672)、(680±529)、(587±520)μg/ml,명현저우HP전(1659±1105)μg/ml,차이유통계학의의(P<0.01).관류기흡부갑알린함량양성.결론 HP가이명현강저갑알린중독환자혈청중독물농도,실험방법직접증명료림상응용HP적탄신학능흡부갑알린.
Objective To explore the effect of hemoperfusion(HP) about the pacients of methamidophos poisoning.Methods On the basis of comprehensive treatment,15 cases of severe acute methamidophos poisoning patients were treated with HP,Blood samples were collected at 7 time points,before and 5,15,30,45,60mins following the beginning and the end of hemoperfusion.Blood samples were used for measuring the concentration of methamidophos and perfusion devices were used for measuring the volume of methamidophos adsorbed by the device after hemoperfusion.Results 15 patients live in 12 cases,3 cases of death.HP (former) blood Cholinesterase vigor were 662.60 + 632.05,HP (after) blood cholinesterase vigor were 2577.52 + 920.38 IU/L;The difference of blood Cholinesterase vigor between the before and after HP was statistically significant (P < 0.01).The patients' methamidophos concentration of blood when HP treated 45,60,120 min were respectively (851 + 672),(680 + 529),(587 + 520) μg /ml,there were significantly lower than that the patients' methamidophos concentration of blood who were before HP (1659 +1105) μg/ml,a statistically significant difference (P<0.01).Conclusion HP can be cut down obviously methamidophos poisoning patients serum concentrations of toxic,the experimental method directly prove the clinical application of carbon HP can really adsorption methamidophos.
