中华流行病学杂志
中華流行病學雜誌
중화류행병학잡지
CHINESE JOURNAL OF EPIDEMIOLOGY
2010年
7期
812-814
,共3页
邱宏%余德新%谢立亚%王晓蓉%付振明
邱宏%餘德新%謝立亞%王曉蓉%付振明
구굉%여덕신%사립아%왕효용%부진명
logistic回归模型%连续变量%相加交互作用S指数%方法,Bootstrap
logistic迴歸模型%連續變量%相加交互作用S指數%方法,Bootstrap
logistic회귀모형%련속변량%상가교호작용S지수%방법,Bootstrap
Logistic regression model%Continuous variableInteraction departure from additivity,Synergy index%Bootstrap
Rothman提出生物学交互作用的评价应该基于相加尺度即是否有相加交互作用,而logistic回归模型的乘积项反映的是相乘交互作用.目前国内外文献讨论logistic回归模型中两因素的相加交互作用以两分类变量为主,本文介绍两连续变量或连续变量与分类变量相加交互作用可信区间估计的Bootstrap方法,文中以香港男性肺癌病例对照研究资料为例,辅以免费软件R的实现程序,为研究人员分析交互作用提供参考.
Rothman提齣生物學交互作用的評價應該基于相加呎度即是否有相加交互作用,而logistic迴歸模型的乘積項反映的是相乘交互作用.目前國內外文獻討論logistic迴歸模型中兩因素的相加交互作用以兩分類變量為主,本文介紹兩連續變量或連續變量與分類變量相加交互作用可信區間估計的Bootstrap方法,文中以香港男性肺癌病例對照研究資料為例,輔以免費軟件R的實現程序,為研究人員分析交互作用提供參攷.
Rothman제출생물학교호작용적평개응해기우상가척도즉시부유상가교호작용,이logistic회귀모형적승적항반영적시상승교호작용.목전국내외문헌토론logistic회귀모형중량인소적상가교호작용이량분류변량위주,본문개소량련속변량혹련속변량여분류변량상가교호작용가신구간고계적Bootstrap방법,문중이향항남성폐암병례대조연구자료위례,보이면비연건R적실현정서,위연구인원분석교호작용제공삼고.
Rothman argued that interaction estimated as departure from additivity better reflected the biological interaction. In a logistic regression model, the product term reflects the interaction as departure from multiplicativity. So far, literature on estimating interaction regarding an additive scale using logistic regression was only focusing on two dichotomous factors. The objective of the present report was to provide a method to examine the interaction as departure from additivity between two continuous variables or between one continuous variable and one categorical variable.We used data from a lung cancer case-control study among males in Hong Kong as an example to illustrate the bootstrap re-sampling method for calculating the corresponding confidence intervals.Free software R (Version 2.8.1) was used to estimate interaction on the additive scale.
