中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2011年
3期
303-304
,共2页
周庆玉%李金华%宫涛%郭洪敏
週慶玉%李金華%宮濤%郭洪敏
주경옥%리금화%궁도%곽홍민
骨折%白细胞介素类%肿瘤坏死因子α%C反应蛋白质%骨钙素%老年人
骨摺%白細胞介素類%腫瘤壞死因子α%C反應蛋白質%骨鈣素%老年人
골절%백세포개소류%종류배사인자α%C반응단백질%골개소%노년인
Bone fracture%Interleukins%Tumor necrosis factor-alpha%C-reactive protein%Osteocalcin%Aged
目的 探讨老年股骨颈骨折患者围术期血清炎性因子水平变化规律及临床意义.方法 选取62例老年股骨颈骨折患者为研究对象,采用ELISA法分别于术前1天、术后第1、3、7及14天检测血清白细胞介素-1(IL-1)、白细胞介素-6(IL-6)、白细胞介素-10(IL-10)、肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)及骨谷氨酸蛋白(BGP)水平.结果 62例患者围术期血清IL-1、IL-6、IL-10、TNF-α水平均呈现先升后降趋势,术后第3天时为最高,与术前比差异均有统计学意义(t=3.34、3.53、3.44、3.69,均P＜0.05),术后第14天恢复至术前水平;而血清BGP水平则一直在呈现上升的趋势,至术后第14天升至最高,较术前差异有统计学意义(t=2.87,P＜0.05).结论 老年股骨颈骨折患者围术期血清IL-1、IL-6、IL-10、TNF-α、CRP及BGP水平均呈现一定的变化规律,其检测对于了解患者的疾病发展及转归有着积极的意义.
目的 探討老年股骨頸骨摺患者圍術期血清炎性因子水平變化規律及臨床意義.方法 選取62例老年股骨頸骨摺患者為研究對象,採用ELISA法分彆于術前1天、術後第1、3、7及14天檢測血清白細胞介素-1(IL-1)、白細胞介素-6(IL-6)、白細胞介素-10(IL-10)、腫瘤壞死因子-α(TNF-α)、C反應蛋白(CRP)及骨穀氨痠蛋白(BGP)水平.結果 62例患者圍術期血清IL-1、IL-6、IL-10、TNF-α水平均呈現先升後降趨勢,術後第3天時為最高,與術前比差異均有統計學意義(t=3.34、3.53、3.44、3.69,均P＜0.05),術後第14天恢複至術前水平;而血清BGP水平則一直在呈現上升的趨勢,至術後第14天升至最高,較術前差異有統計學意義(t=2.87,P＜0.05).結論 老年股骨頸骨摺患者圍術期血清IL-1、IL-6、IL-10、TNF-α、CRP及BGP水平均呈現一定的變化規律,其檢測對于瞭解患者的疾病髮展及轉歸有著積極的意義.
목적 탐토노년고골경골절환자위술기혈청염성인자수평변화규률급림상의의.방법 선취62례노년고골경골절환자위연구대상,채용ELISA법분별우술전1천、술후제1、3、7급14천검측혈청백세포개소-1(IL-1)、백세포개소-6(IL-6)、백세포개소-10(IL-10)、종류배사인자-α(TNF-α)、C반응단백(CRP)급골곡안산단백(BGP)수평.결과 62례환자위술기혈청IL-1、IL-6、IL-10、TNF-α수평균정현선승후강추세,술후제3천시위최고,여술전비차이균유통계학의의(t=3.34、3.53、3.44、3.69,균P＜0.05),술후제14천회복지술전수평;이혈청BGP수평칙일직재정현상승적추세,지술후제14천승지최고,교술전차이유통계학의의(t=2.87,P＜0.05).결론 노년고골경골절환자위술기혈청IL-1、IL-6、IL-10、TNF-α、CRP급BGP수평균정현일정적변화규률,기검측대우료해환자적질병발전급전귀유착적겁적의의.
Objective To study the clinical significance and change law of the serum inflammatory factor in the elder patients with femoral neck fracture during perioperative period. Methods 62 patients with femoral neck fracture were selected as research object,and the serum IL-1,IL-6,IL-10,TNF-α,CRP and BGP of the patients at preoperative day and after the treatment at the first,third,seventh and fourteenth day were detected with ELISA. Results The serum IL-1 ,IL-6,IL-10,TNF-α and CRP went up first and then down,the levels were highest at the third day, and they were compared to the levels at preoperative day( t = 3.34,3.53,3.44,3.69, all P ＜ 0. 05 ), the levels at the fourteenth day returned to normal levels,but the serum BGP showed a rising trend,the level was highest at the fourteenth day, and it was compared to the level at preoperative day( t = 2. 87, P ＜ 0. 05 ). Conclusion The changes of the serum inflammatory factor in the elder patients with femoral neck fracture during periopearative period showed regular pattern, and it was meaningful for understanding the developing and prognosis.
