中华神经医学杂志
中華神經醫學雜誌
중화신경의학잡지
CHINESE JOURNAL OF NEUROMEDICINE
2011年
9期
934-937
,共4页
魏社鹏%赵继宗%周范民%丁侃%张巍峰%孙志扬%张燕飞%魏亮%杨成%张夔鸣
魏社鵬%趙繼宗%週範民%丁侃%張巍峰%孫誌颺%張燕飛%魏亮%楊成%張夔鳴
위사붕%조계종%주범민%정간%장외봉%손지양%장연비%위량%양성%장기명
泌乳素%高泌乳素血症%泌乳素微腺瘤%溴隐亭
泌乳素%高泌乳素血癥%泌乳素微腺瘤%溴隱亭
비유소%고비유소혈증%비유소미선류%추은정
Prolactin%Hyperprolactinemia%Microprolactinoma%Bromocriptine
目的探讨高泌乳素血症(HPRL)的临床表现、治疗方法及其与泌乳素腺瘤的关系。方法分析同济大学附属东方医院神经外科自2005年1月至2010年1月确诊为HPRL的166例患者临床资料、激素指标，其中4年为回顾性分析，1年为前瞻性研究。 结果大部分患者的年龄分布在20～40岁，月经不调是最常见的临床表现，见于141例患者(84.9％)；其次是溢乳，见于114例患者(68.7％)。发病原因中，泌乳素微腺瘤见于62例患者(37.3％)，无功能性垂体大腺瘤见于26例患者(15.7％)。泌乳素微腺瘤患者泌乳素水平为(161.2±60.6)ng/mL，和其他任一原因导致的HPRL患者泌乳素水平比较，差异均有统计学意义(P≤0.05)。 结论泌乳素微腺瘤是HPRL最常见的病因，其次为特发性HPRL。单从血清泌乳素的水平并不能确定患者是否一定存在微腺瘤。
目的探討高泌乳素血癥(HPRL)的臨床錶現、治療方法及其與泌乳素腺瘤的關繫。方法分析同濟大學附屬東方醫院神經外科自2005年1月至2010年1月確診為HPRL的166例患者臨床資料、激素指標，其中4年為迴顧性分析，1年為前瞻性研究。 結果大部分患者的年齡分佈在20～40歲，月經不調是最常見的臨床錶現，見于141例患者(84.9％)；其次是溢乳，見于114例患者(68.7％)。髮病原因中，泌乳素微腺瘤見于62例患者(37.3％)，無功能性垂體大腺瘤見于26例患者(15.7％)。泌乳素微腺瘤患者泌乳素水平為(161.2±60.6)ng/mL，和其他任一原因導緻的HPRL患者泌乳素水平比較，差異均有統計學意義(P≤0.05)。 結論泌乳素微腺瘤是HPRL最常見的病因，其次為特髮性HPRL。單從血清泌乳素的水平併不能確定患者是否一定存在微腺瘤。
목적탐토고비유소혈증(HPRL)적림상표현、치료방법급기여비유소선류적관계。방법분석동제대학부속동방의원신경외과자2005년1월지2010년1월학진위HPRL적166례환자림상자료、격소지표，기중4년위회고성분석，1년위전첨성연구。 결과대부분환자적년령분포재20～40세，월경불조시최상견적림상표현，견우141례환자(84.9％)；기차시일유，견우114례환자(68.7％)。발병원인중，비유소미선류견우62례환자(37.3％)，무공능성수체대선류견우26례환자(15.7％)。비유소미선류환자비유소수평위(161.2±60.6)ng/mL，화기타임일원인도치적HPRL환자비유소수평비교，차이균유통계학의의(P≤0.05)。 결론비유소미선류시HPRL최상견적병인，기차위특발성HPRL。단종혈청비유소적수평병불능학정환자시부일정존재미선류。
Objective To study the clinical manifestations and treatment methods of hyperprolactinemia (HPRL), a common disorder encountered in clinical practice, and explore its association with prolactinomas. Methods The clinical data, hormone profile and imaging data of 166females with documented HPRL, admitted to our hospital from January 2005 to January 2010, for over a period of 5 years, including 4 years of retrospective analysis and 1 year of prospective study, were retrospectively analyzed. Results Most patients aged 20-40 with abnormal menstruation as their most common symptom; 141 patients (84.9％) appeared abnormal menstruation and 1 14 (68.7％) with galactorrhea. Microadenoma was noted in 62 patients (37.3％), nonfunctioning pituitary macroadenoma involved stalk occurred in 26 patients (15.7％). As compared with that in patients with idiopathic HPRL ([93.9±20.4]ng/mL), the level ofprolactin in patients with microprolactinoma ([161.2±60.6]ng/mL) was significantly higher (P＜0.05); as compared with that in patients with prolactin microadenoma, the level of prolactin in patients with domperidone caused drug-induced HPRL ([240.2±29.4]ng/mL) was obviously increased (P＜0.05). Conclusion We cannot confirm whether a HPRL patient has prolactinomas only through detecting the level of prolactin. Microprolactinoma is the most common cause of HPRL, followed by idiopathic cause.
