CAJ | 학술논문

目的:观察不同碘摄入水平甲状腺功能正常的健康成人对甲状腺功能的影响.方法:选择甲状腺功能正常的健康志愿者161例,随机分为7组,各组每人每天分别服用500 μg,750 μg,1 000 μg,1 250 μg,1 500 μg,1 750 μg,2000 μg的碘补充剂,为期4周.采用化学发光法测定血清F13、F14、sTSH浓度.结果:与补碘前相比,补碘后各组受试者血清FT3在正常值范围内呈下降趋势,除1 250 μg和1 750 μg剂量组外其余各组差异有统计学意义(P＜0.05或P＜0.01);补碘后血清FT4呈轻度下降趋势,至1 500 μg剂量组时,在正常值范围内明显下降(P＜0.05或P＜0.01);各组人群在补充碘剂2周后(500 μg和750 μg组在4周后)血清sTSH明显卜升(P＜0.05或P＜0.01).各剂量组间血清FT3、FT4和sTSH相比差异无统计学意义(均P＞0.05).结论:碘营养充足的人群短期高剂量碘摄入时表现为血清sTSH水平增高.
목적:관찰불동전섭입수평갑상선공능정상적건강성인대갑상선공능적영향.방법:선택갑상선공능정상적건강지원자161례,수궤분위7조,각조매인매천분별복용500 μg,750 μg,1 000 μg,1 250 μg,1 500 μg,1 750 μg,2000 μg적전보충제,위기4주.채용화학발광법측정혈청F13、F14、sTSH농도.결과:여보전전상비,보전후각조수시자혈청FT3재정상치범위내정하강추세,제1 250 μg화1 750 μg제량조외기여각조차이유통계학의의(P＜0.05혹P＜0.01);보전후혈청FT4정경도하강추세,지1 500 μg제량조시,재정상치범위내명현하강(P＜0.05혹P＜0.01);각조인군재보충전제2주후(500 μg화750 μg조재4주후)혈청sTSH명현복승(P＜0.05혹P＜0.01).각제량조간혈청FT3、FT4화sTSH상비차이무통계학의의(균P＞0.05).결론:전영양충족적인군단기고제량전섭입시표현위혈청sTSH수평증고.
Objective:To observe the effect of different iodine intake on the thyroid function in euthyroid adult persons.Methods:One hundred and sixty-one euthyroid healthy volunteers aged 18-24 years were randomly divided into 7 groups.Each group was assigned to receive 500 μg,750 μg,1 000 μg,1 250 μg,1 500 μg,and 2 000 μg iodide/day for four weeks.Serum concentrations of free triiodothyronine(FT3),free thyroxin(FT4)and sensitive thyroid-stimulating hormone(sTSH)were measured by chemolumineseenee assays.Results:Serum FT3 concentration was found a small decline within the normal range in all the iodide supplemented groups(P ＜ 0.05).The level of FT4 was significantly lower,when the dose was up to 1 500 μg (P ＜ 0.05).The level of serum sTSH was increased after 2 weeks iodide supplement in all groups,and after 4 weeks in 500 μg and 750 μg groups(P ＜ 0.05).No significant changes were observed in FT3,FT4 and sTSH between groups(P＞ 0.05).Conclusion:The thyroid function of normal people showed a rise in serum sTSH at a short time and a high-dose of iodine intake.