CAJ | 학술논문

目的：旨在调查中国潮汕食管癌高发区一些常见食品如鱼露、酸菜、咸鱼、咸肉、熏制食品、水果以及蔬菜等的食管癌病因学作用。方法：应用病例棗对照方法，共调查1248例食管鳞状细胞癌病例及1248例按年龄、性别的对照，采用条件Logistic回归对资料进行统计分析。结果：调整职业、居住地、经济收入、饮酒、吸烟和饮茶等因素后，发现食用鱼露和酸菜有显著的食管癌危险作用，水果对食管癌具有明显的保护效应。食用咸鱼和咸肉的危险度均升高，但剂量-效应关系无统计学显著性。没有发现蔬菜和熏制食品对食管癌有明显致癌效应。结论：进一步提示鱼露和酸菜与人群中的高食管癌危险性相关，但两者间的生物学因果关系需进一步的流行病学和实验研究证实。
목적：지재조사중국조산식관암고발구일사상견식품여어로、산채、함어、함육、훈제식품、수과이급소채등적식관암병인학작용。방법：응용병례조대조방법，공조사1248례식관린상세포암병례급1248례안년령、성별적대조，채용조건Logistic회귀대자료진행통계분석。결과：조정직업、거주지、경제수입、음주、흡연화음다등인소후，발현식용어로화산채유현저적식관암위험작용，수과대식관암구유명현적보호효응。식용함어화함육적위험도균승고，단제량-효응관계무통계학현저성。몰유발현소채화훈제식품대식관암유명현치암효응。결론：진일보제시어로화산채여인군중적고식관암위험성상관，단량자간적생물학인과관계수진일보적류행병학화실험연구증실。
Objective： The current study was designed to investigate the role of foods such as fish juice, pickles, bacon, salted fish, smoked food, fruit and vegetables in the etiology of esophageal cancer in Chaoshan region of China. Method： A large case-control study was conducted to investigate 1248 patients with squamous cell carcinoma of the esophagus and 1248 controls matched by sex and age. Results： After adjusting for the effects of occupation, areas of residence, income, alcohol, cigarette and tea, a strong association with a clear dose-response was observed between the frequencies of fish juice eating and esophageal cancer (P<0.01), and the relative risk for women was 23.5 and for men was 3.1, respectively. The results for pickles were similar to fish juice. A protective effect of fruits on esophageal cancer was observed both in women (OR=0.13) and in men (OR=0.46), and the risk was decreased (P< 0.01) as frequencies of fruits eating was increased. The risks were significantly higher in bacon and salted fish consumers than that in non-consumer, but the dose-response relationship was not significant. No significant effects, however, were detected in vegetables and smoked food consumption. Conclusions:To the authors' knowledge, this is the first report on relationship between the fish juice and high risk of esophageal cancer in population. Further epidemiological and experiment study are required to find a biological causal relationship between them.