CAJ | 학술논문

背景内源性孕激素黄体酮不但是性激素,也是神经类固醇激素的一种,对神经发育、修复及相关疾病[如阿尔茨海默病(alzheimer's diseage,AD)]有重要影响.而越来越多的合成孕激素对神经系统的影响也渐受到研究人员的关注.目的综述近年来孕激素与AD及认知功能关系相关文献,并阐释其可能机制,为研究合成的孕激素提供思路.内容大量文献数据提示,黄体酮对AD发生发展及认知功能有积极作用,而合成的孕激素乙酸甲氧基孕酮则不然.现从细胞、动物实验及临床研究3个层面,从分子水平和功能研究,从学习记忆基础和AD发病成因等方面阐述其可能机制.趋向越来越多的合成孕激素应用于临床,它们对AD发病和认知功能的影响有待于进一步阐明.
배경 내원성잉격소황체동불단시성격소,야시신경류고순격소적일충,대신경발육、수복급상관질병[여아이자해묵병(alzheimer's diseage,AD)]유중요영향.이월래월다적합성잉격소대신경계통적영향야점수도연구인원적관주.목적 종술근년래잉격소여AD급인지공능관계상관문헌,병천석기가능궤제,위연구합성적잉격소제공사로.내용 대량문헌수거제시,황체동대AD발생발전급인지공능유적겁작용,이합성적잉격소을산갑양기잉동칙불연.현종세포、동물실험급림상연구3개층면,종분자수평화공능연구,종학습기억기출화AD발병성인등방면천술기가능궤제.추향 월래월다적합성잉격소응용우림상,타문대AD발병화인지공능적영향유대우진일보천명.
Background Endogenous progestin, progesterone, is not only a gonadal hormone, but also one of the neurosteroids, which exerts profound effects on neurogenesis, repair and central nervous system related diseases, such as Alzheimer's disease (AD). As more and more synthetic progestins are being introduced into clinical application, their effects on nervous system are attracting researchers' concern. Purpose Recent literature on the relationship between progestins and Alzheimer's disease or cognitive function was reviewed to provide some mechanism-based ideas for further research on artificial progestins. Content A great amount of literature suggested that progesterone had beneficial effects on AD and cognitive function, while the synthetic progestin methoxyprogesterone acetate (MPA) had adverse effects. The possible mechanisms are elucidated in this review based upon the results of cell culture, animal experiment and clinic research, from different aspects of molecular mechanism, functional research, basis oflearning and memory and pathogenesis of AD. Trend More and more artificial progestins are being used in the clinic, however, their impacts on AD development and cognitive functions still need to be further expounded.