CAJ | 학술논문

目的探讨粪便隐血免疫双联法在监测服用小剂量肠溶阿司匹林(ASA)致消化道出血中的应用价值.方法对328例需长期服用小剂量ASA的患者和对照组30例,要求不服用口服抗凝剂、无消化道出血征象的心脑血管疾病患者,分别于服药前、服用1周、1个月、3个月、6个月应用隐血免疫双联法(血红蛋白免疫法和转铁蛋白免疫法)检测粪便隐血,阳性者再行胃镜检查,确定上消化道出血与否.结果 ①治疗组328例检出粪便隐血免疫双联法阳性40例,阳性率(12.2％),与对照组(3.3％)比较,差异有显著性(P＜0.05);②治疗组粪便隐血免疫双联法阳性40例中行胃镜检查29例,示病理意义24例,另外5例的粪便隐血血红蛋白免疫法及转铁蛋白免疫法却都阳性；③治疗组粪便隐血免疫双联法阳性40例的出血监测时间差异无显著性(P＞0.05).结论可以常规应用粪便隐血免疫双联法监测长期服用小剂量ASA引起的消化道出血.
목적 탐토분편은혈면역쌍련법재감측복용소제량장용아사필림(ASA)치소화도출혈중적응용개치.방법 대328례수장기복용소제량ASA적환자화대조조30례,요구불복용구복항응제、무소화도출혈정상적심뇌혈관질병환자,분별우복약전、복용1주、1개월、3개월、6개월응용은혈면역쌍련법(혈홍단백면역법화전철단백면역법)검측분편은혈,양성자재행위경검사,학정상소화도출혈여부.결과 ①치료조328례검출분편은혈면역쌍련법양성40례,양성솔(12.2％),여대조조(3.3％)비교,차이유현저성(P＜0.05);②치료조분편은혈면역쌍련법양성40례중행위경검사29례,시병리의의24례,령외5례적분편은혈혈홍단백면역법급전철단백면역법각도양성；③치료조분편은혈면역쌍련법양성40례적출혈감측시간차이무현저성(P＞0.05).결론 가이상규응용분편은혈면역쌍련법감측장기복용소제량ASA인기적소화도출혈.
Objective To explore the application value of dejecta occult blood coupled with hemoglobin and/or transferrin monoclonal immunoassay on inspect gastrointestinal bleeding induced by taking low-dose ASA.Methods 328 cases taking low-dose ASA in long-time were set as therapy group;30 cases patients with Heart-Brain vas disease not taking ASA and not having the sign of gastrointestinal bleeding were set as control group,Detected dejecta occult blood with hemoglobin and/or transferrin monoclonal immunoassay 1 week,1 month,3 months,6 months before taking medicine.Took Gastroscopy if dejecta occult blood were positive to see if upper gastrointestinal were bleeding or not.Results ① Among these 328 patients,dejecta occult blood was detected with hemoglobin and/or transferrin monoclonal immunoassay; 40 cases were positive( 12.2％ )in therapy group,while control group had 1 case(3.3％,1/30);there was statistical difference ( P ＜ 0.05 ).② There were 29 cases taking Gastroscopy of 40 cases whose dejecta occult blood was positive; 24 cases had pathology significance; hemoglobin and transferrin monoclonal immunoassay was positive of the other 5 cases.③There was no statistical significant difference on bleeding time (P＞ 0.05 ).Conclusion Dejecta occult blood detected with hemoglobin and/or transferrin monoclonal immunoassay could be a routine inspection for gastrointestinal bleeding induced by taking low-dose ASA in long-time.