CAJ | 학술논문

目的观察小儿心脏手术体外循环中预充6%羟乙基淀粉(Volven130/0.4)对血流动力学及凝血功能的影响.方法60例体外循环低温全麻心脏手术患儿,随机分为对照组(C组)和羟乙基淀粉组(V组),每组30例,C组在体外循环中预充血浆400 ml,V组在体外循环中预充羟乙基淀粉400 ml.体外循环前、后监测心率(HR)、平均动脉血压(MAP)、中心静脉压(CVP).体外循环前、后分别抽取静脉血测定:①红细胞比容(HCT),血沉(BSR);②血小板计数(PLC),凝血酶原时间(PT),激活全血凝固时间(ACT).观察术前、心肺转流15min、返回ICU时及术后24h上述指标的变化.结果两组HCT、PLC在体外循环后均显著降低,全血血沉均显著加快,两组心率、MAP、CVP、PLC、ACT、PT体外循环前、后差异均无统计学意义(均P＞0.05).结论6%羟乙基淀粉血液稀释用于小儿心内直视手术安全有益.
목적 관찰소인심장수술체외순배중예충6%간을기정분(Volven130/0.4)대혈류동역학급응혈공능적영향.방법60례체외순배저온전마심장수술환인,수궤분위대조조(C조)화간을기정분조(V조),매조30례,C조재체외순배중예충혈장400 ml,V조재체외순배중예충간을기정분400 ml.체외순배전、후감측심솔(HR)、평균동맥혈압(MAP)、중심정맥압(CVP).체외순배전、후분별추취정맥혈측정:①홍세포비용(HCT),혈침(BSR);②혈소판계수(PLC),응혈매원시간(PT),격활전혈응고시간(ACT).관찰술전、심폐전류15min、반회ICU시급술후24h상술지표적변화.결과 량조HCT、PLC재체외순배후균현저강저,전혈혈침균현저가쾌,량조심솔、MAP、CVP、PLC、ACT、PT체외순배전、후차이균무통계학의의(균P＞0.05).결론6%간을기정분혈액희석용우소인심내직시수술안전유익.
Objective To observe the effects of 6%hydroxyethyl starch(Volven 130/0.4)infusion on hemodynamics and coagulation.Methods 60 cases of open heart surgical children under cardiopulmonary bypass were randomly divided into two groups(30 cases for each):The control group(group C)were infused with 400 ml plasma and volven group(group V)were infused with 400 ml Volven before cardiopulmonary bypass.Then mean aterial pressrue(MAP),heart rate(HR),and central venous pressure(CVP)were measured.The venous blood samples were collected before and after infusion for the measurements of the following parameters:haematocrit(HCT),blood sedimentation(BSR),platelet count(PLC),prothrombin time(PT),and activated whole blood clot time(ACT).Those indexes before operation,15 min after bypass,after returning to ICU,and 24 hours after operation were observed.Results HCT and PLC after infusion were significantly lower than that before infusion.BSR after infusion was significantly faster than that before infusion.There were no significant changes in MAP,HR,CVP,PLC,ACT and PT.Conclusion 6%Hydroxyethyl starch infusion is safe and beneficial during cardiopulmonary bypass.