国际医药卫生导报
國際醫藥衛生導報
국제의약위생도보
INTERNATIONAL MEDICINE & HEALTH GUIDANCE NEWS
2012年
5期
737-740
,共4页
手足口病%肠道病毒71型(EV71)%柯萨奇病毒A组16型(CoxA 16)%病原学
手足口病%腸道病毒71型(EV71)%柯薩奇病毒A組16型(CoxA 16)%病原學
수족구병%장도병독71형(EV71)%가살기병독A조16형(CoxA 16)%병원학
Hand-foot-and-mouth disease%EV71%Cox A16%Etiology
目的 了解惠州市手足口病流行期间(2009-2010年4-10月)的病原学特征及流行病学规律,为科学制定手足口病防控策略提供依据.方法 2009-2010年手足口病流行期间共收集578份疑似手足口病标本,用荧光定量RT-PCR法进行肠道病毒通用型、肠道病毒71型( EV71)和柯萨奇病毒A组16型(CoxA 16)定量分型.结果 578例被检测患儿中406例为肠道病毒阳性,阳性率为70.24％; EV71阳性208份,检出率为35.99％; CoxA16阳性145份,检出率为25.09％；手足口病2009年以CoxA 16流行为主,2010年以EV71流行为主.手足口病重症病例EV71阳性率为81.55％.手足口病发病以幼儿为主,主要集中在4岁以下儿童,占83.91％.结论 手足口病在不同时期的肠道病毒感染往往呈现不同的流行特点,年龄小于3岁的EV71阳性手足口病患儿已成为重症病例的危险因子.及时、持续地开展手足口病病原学调查,预测其流行规律,有助于更好的制定其防控措施.
目的 瞭解惠州市手足口病流行期間(2009-2010年4-10月)的病原學特徵及流行病學規律,為科學製定手足口病防控策略提供依據.方法 2009-2010年手足口病流行期間共收集578份疑似手足口病標本,用熒光定量RT-PCR法進行腸道病毒通用型、腸道病毒71型( EV71)和柯薩奇病毒A組16型(CoxA 16)定量分型.結果 578例被檢測患兒中406例為腸道病毒暘性,暘性率為70.24％; EV71暘性208份,檢齣率為35.99％; CoxA16暘性145份,檢齣率為25.09％；手足口病2009年以CoxA 16流行為主,2010年以EV71流行為主.手足口病重癥病例EV71暘性率為81.55％.手足口病髮病以幼兒為主,主要集中在4歲以下兒童,佔83.91％.結論 手足口病在不同時期的腸道病毒感染往往呈現不同的流行特點,年齡小于3歲的EV71暘性手足口病患兒已成為重癥病例的危險因子.及時、持續地開展手足口病病原學調查,預測其流行規律,有助于更好的製定其防控措施.
목적 료해혜주시수족구병류행기간(2009-2010년4-10월)적병원학특정급류행병학규률,위과학제정수족구병방공책략제공의거.방법 2009-2010년수족구병류행기간공수집578빈의사수족구병표본,용형광정량RT-PCR법진행장도병독통용형、장도병독71형( EV71)화가살기병독A조16형(CoxA 16)정량분형.결과 578례피검측환인중406례위장도병독양성,양성솔위70.24％; EV71양성208빈,검출솔위35.99％; CoxA16양성145빈,검출솔위25.09％；수족구병2009년이CoxA 16류행위주,2010년이EV71류행위주.수족구병중증병례EV71양성솔위81.55％.수족구병발병이유인위주,주요집중재4세이하인동,점83.91％.결론 수족구병재불동시기적장도병독감염왕왕정현불동적류행특점,년령소우3세적EV71양성수족구병환인이성위중증병례적위험인자.급시、지속지개전수족구병병원학조사,예측기류행규률,유조우경호적제정기방공조시.
Objective To provides scientific basis for making measures for prevention and control of hand-foot-mouth disease ( HFMD ) by investigating the epidemic characteristics of etiological features of the disorder.Methods A total of 578 children with HFMD were enrolled from April 2009 to October 2010.Enterovirus universal type ( pan-EV ) and type 71 ( EV71 ) and coxsackie virus group A 16 ( CoxA 16 ) were detected by real-time RT-PCR.Results 406 of 578 ( 70.24％ ) children were positive with pan-EV,208 ( 35.99％ )were positive with EV71,and 145 were positive with CoxA 16.CoxA 16 was the leading pathogen in 2009 and EV71 infection was prevalent in 2010.The epidemic characteristics of enterovirus infection differed significnatly between severe and mild HFMD.The EV71 positive rate was 81.55％ in the children with severe HFMD.HFMD mainly occurred in younger children,especially in those under 4,accounting for 83.91％.Conclusions Hand-foot-mouth disease has different epidemic characteristics at different times of enterovirus infection.Children with EV71 infection who are under 3 are at high risk for severe HFMD.Prompt epidemical investigation of hand-foot-mouth disease and prediction of spreading features is helpful for making better measures for the prevention and control of the disorder.
