中国医药
中國醫藥
중국의약
CHINA MEDICINE
2010年
10期
940-942
,共3页
心理疗法%镇痛,病人控制%细胞因子类%直肠肿瘤
心理療法%鎮痛,病人控製%細胞因子類%直腸腫瘤
심리요법%진통,병인공제%세포인자류%직장종류
Psychotherapy%Analgesia,patient-controlled%Cytookines%Radical neoplasms
目的 探讨心理干预联合自控镇痛技术对直肠癌根治术后患者血清炎性细胞因子的影响及临床意义.方法 将60例拟行自肠癌根治术的患者完全随机分为对照组、全身麻醉组和心理干预联合静脉自控镇痛组(联合组),每组20例.测定不同时间患者血清白细胞介素(IL)-6、IL-8和肿瘤坏死因子α(TNF-α)含量,进行术后疼痛视觉模拟评分.结果 联合组术后不同时间点视觉模拟评分均明显低于同时间点的对照组.比较术后48 h联合组与对照组患者血清IL-6[(65.3±7.5)ng/L比(79.4±8.2)ng/L]、IL-8[(62.7±7.5)ng/L比(88.9±6.5)ng/L]和TNF-α[(16.4±1.8)Pg/L比(21.1±1.2)pg/L]的含量,联合组上述指标显著低于同时间点的对照组(P＜0.05或P＜0.01).结论 围术期实行心理干预联合术后静脉镇痛,可有效地降低患者血清炎性细胞因子水平,调控围术期的免疫功能.
目的 探討心理榦預聯閤自控鎮痛技術對直腸癌根治術後患者血清炎性細胞因子的影響及臨床意義.方法 將60例擬行自腸癌根治術的患者完全隨機分為對照組、全身痳醉組和心理榦預聯閤靜脈自控鎮痛組(聯閤組),每組20例.測定不同時間患者血清白細胞介素(IL)-6、IL-8和腫瘤壞死因子α(TNF-α)含量,進行術後疼痛視覺模擬評分.結果 聯閤組術後不同時間點視覺模擬評分均明顯低于同時間點的對照組.比較術後48 h聯閤組與對照組患者血清IL-6[(65.3±7.5)ng/L比(79.4±8.2)ng/L]、IL-8[(62.7±7.5)ng/L比(88.9±6.5)ng/L]和TNF-α[(16.4±1.8)Pg/L比(21.1±1.2)pg/L]的含量,聯閤組上述指標顯著低于同時間點的對照組(P＜0.05或P＜0.01).結論 圍術期實行心理榦預聯閤術後靜脈鎮痛,可有效地降低患者血清炎性細胞因子水平,調控圍術期的免疫功能.
목적 탐토심리간예연합자공진통기술대직장암근치술후환자혈청염성세포인자적영향급림상의의.방법 장60례의행자장암근치술적환자완전수궤분위대조조、전신마취조화심리간예연합정맥자공진통조(연합조),매조20례.측정불동시간환자혈청백세포개소(IL)-6、IL-8화종류배사인자α(TNF-α)함량,진행술후동통시각모의평분.결과 연합조술후불동시간점시각모의평분균명현저우동시간점적대조조.비교술후48 h연합조여대조조환자혈청IL-6[(65.3±7.5)ng/L비(79.4±8.2)ng/L]、IL-8[(62.7±7.5)ng/L비(88.9±6.5)ng/L]화TNF-α[(16.4±1.8)Pg/L비(21.1±1.2)pg/L]적함량,연합조상술지표현저저우동시간점적대조조(P＜0.05혹P＜0.01).결론 위술기실행심리간예연합술후정맥진통,가유효지강저환자혈청염성세포인자수평,조공위술기적면역공능.
Objective To investigate the effect of psychological intervention combined with patient-controlled analgesia on serum levels of IL-6, IL-8 and TNF-α in patients undergoing radical rectal cancer surgery.Methods Sixty patients scheduled for radical rectal cancer surgery were randomly allocated to the control group,patient controll intravenous analgesia group ( PCIA group) and the perioperative psychological intervention combined with the PCIA group. Venous blood samples were obtained at different time points to determine the levels of plasma IL-6, IL-8 and TNF-α. Postoperative pain was assessed by visual analog scale (VAS). Results Serum levels of IL-6, IL-8 and TNF-α in the perioperative psychological intervention group were signifcantly lower than the other two groups after operation ( P ＜ 0.05 or P ＜ 0. 01 ). The content of IL-6 [ ( 65.3 ± 7.5 ) vs ( 79.4 ± 8.2 ) ng/L), IL-8[(62.7±7.5) vs (88.9 ±6.5)ng/L] and TNF-α [(16.4 ±1.3) vs (21.1 ± 1.2)ng/L] in the perioperative psychological intervention group were signifcantly lower than the other two groups after operation 48 h ( P ＜ 0.05 ).Decreased VAS scores could also be oberserved in the combined group. Conclusion Psychological intervention combined with patient-controlled analgesia can effectively provide analgesic effect and control stress-inflamatory responses in patients after radical rectal cancer surgery.
