CAJ | 학술논문

目的探讨家族性胃癌的临床病理特征及预后,以提高家族性胃癌的诊治水平.方法回顾性分析大连医科大学附属第二医院1995-2005年收治的67例家族性胃癌患者的临床和随访资料,并与同期收治的具有完整资料的820例散发性胃癌患者进行比较.结果与散发性胃癌相比,家族性胃癌患者中45岁以下者[ 34.3％(23/67)比14.6％(120/820)]、早期胃癌者[23.9％(16/67)比13.8％(108/820)]、弥漫型者[79.1％(53/67)比29.0％(238/820)]及淋巴结转移者[91.0％(61/67)比70.9％(581/820)]比例更高(均P＜0.05).家族性胃癌患者术后5年生存率为20.5％,明显低于散发性胃癌的45.1％(P＜0.05).结论家族性胃癌具有发病年龄早、病期晚、淋巴结转移率高及预后差等特点,其治疗重点在于早期诊断.
목적 탐토가족성위암적림상병리특정급예후,이제고가족성위암적진치수평.방법 회고성분석대련의과대학부속제이의원1995-2005년수치적67례가족성위암환자적림상화수방자료,병여동기수치적구유완정자료적820례산발성위암환자진행비교.결과 여산발성위암상비,가족성위암환자중45세이하자[ 34.3％(23/67)비14.6％(120/820)]、조기위암자[23.9％(16/67)비13.8％(108/820)]、미만형자[79.1％(53/67)비29.0％(238/820)]급림파결전이자[91.0％(61/67)비70.9％(581/820)]비례경고(균P＜0.05).가족성위암환자술후5년생존솔위20.5％,명현저우산발성위암적45.1％(P＜0.05).결론 가족성위암구유발병년령조、병기만、림파결전이솔고급예후차등특점,기치료중점재우조기진단.
Objective To analyze the clinicopathological characteristics and prognosis of familial gastric cancer and to improve the treatment outcome.Methods Clinical data of 67 patients with familial gastric cancer and 820 patients with sporadic gastric cancer in the Second Affiliated Hospital of Dalian Medical University from 1995 to 2005 were retrospectively analyzed.Results Compared to sporadic gastric cancer,the percentage of familial gastric cancer patients less than 45 years old was higher (34.3％ vs.14.6％).Early gastric cancer (23.9％ vs.13.8％),diffuse gastric cancer (79.1％ vs.29.0％),and lymph node metastasis (91.0％ vs.70.9％ ) were more common in patients with familial cancer(P＜0.05).The 5-year survival rate of familial gastric cancer patients was lower than that of patients with sporadic gastric cancer (20.5％ vs.45.1％ )(P＜0.05).Conclusions Familial gastric cancer has characteristics of younger onset age,advanced disease staging,higher positive lymph node ratio and poorer prognosis.Therefore,early diagnosis should be emphasized in the management of familial gastric cancer.