中华围产医学杂志
中華圍產醫學雜誌
중화위산의학잡지
CHINESE JOURNAL OF PERINATAL MEDICINE
2012年
1期
20-24
,共5页
杨旭锦%周丛乐%汤泽中%侯新琳%王红梅%樊曦涌%姜毅
楊旭錦%週叢樂%湯澤中%侯新琳%王紅梅%樊晞湧%薑毅
양욱금%주총악%탕택중%후신림%왕홍매%번희용%강의
婴儿,新生,疾病%感染%中枢神经系统疾病
嬰兒,新生,疾病%感染%中樞神經繫統疾病
영인,신생,질병%감염%중추신경계통질병
Infant,newborn,diseases%Infection%Central nervous system diseases
目的 探讨新生儿感染性疾病与脑损伤的关系. 方法 收集北京大学第一医院新生儿病房2005年11月至2010年8月以感染为主要疾病的1266例新生儿的临床资料,总结脑损伤发生情况,采用Logistic回归模型分析感染所致脑损伤发生的相关因素及重度脑损伤的危险因素.结果 感染性疾病新生儿脑损伤发生率为8.6％(108/1266),其中轻度脑损伤101例(8.0％),重度脑损伤7例(0.6％).重度感染患儿脑损伤发生率为38.7％(29/75),明显高于轻度感染患儿脑损伤的发生率(6.7％,79/1191),差异有统计学意义(x2=92.787,P=0.000).1225例足月儿中存在炎症免疫过程的患儿脑损伤的发生率为13.0％(26/200),明显高于无明显炎症免疫过程者(7.5％,77/1025),差异有统计学意义(x2=6.544,P=0.011).Logistic回归分析显示,重度感染是导致重度脑损伤的独立危险因素(OR=15.750,95％CI:1.756～141.281,P=0.014). 结论 新生儿感染性疾病可导致神经系统损伤,尤其是重度感染或存在炎症免疫过程时发生率更高；感染越重,脑损伤程度越重,尤其是混杂有窒息和低血糖等其他因素时.
目的 探討新生兒感染性疾病與腦損傷的關繫. 方法 收集北京大學第一醫院新生兒病房2005年11月至2010年8月以感染為主要疾病的1266例新生兒的臨床資料,總結腦損傷髮生情況,採用Logistic迴歸模型分析感染所緻腦損傷髮生的相關因素及重度腦損傷的危險因素.結果 感染性疾病新生兒腦損傷髮生率為8.6％(108/1266),其中輕度腦損傷101例(8.0％),重度腦損傷7例(0.6％).重度感染患兒腦損傷髮生率為38.7％(29/75),明顯高于輕度感染患兒腦損傷的髮生率(6.7％,79/1191),差異有統計學意義(x2=92.787,P=0.000).1225例足月兒中存在炎癥免疫過程的患兒腦損傷的髮生率為13.0％(26/200),明顯高于無明顯炎癥免疫過程者(7.5％,77/1025),差異有統計學意義(x2=6.544,P=0.011).Logistic迴歸分析顯示,重度感染是導緻重度腦損傷的獨立危險因素(OR=15.750,95％CI:1.756～141.281,P=0.014). 結論 新生兒感染性疾病可導緻神經繫統損傷,尤其是重度感染或存在炎癥免疫過程時髮生率更高；感染越重,腦損傷程度越重,尤其是混雜有窒息和低血糖等其他因素時.
목적 탐토신생인감염성질병여뇌손상적관계. 방법 수집북경대학제일의원신생인병방2005년11월지2010년8월이감염위주요질병적1266례신생인적림상자료,총결뇌손상발생정황,채용Logistic회귀모형분석감염소치뇌손상발생적상관인소급중도뇌손상적위험인소.결과 감염성질병신생인뇌손상발생솔위8.6％(108/1266),기중경도뇌손상101례(8.0％),중도뇌손상7례(0.6％).중도감염환인뇌손상발생솔위38.7％(29/75),명현고우경도감염환인뇌손상적발생솔(6.7％,79/1191),차이유통계학의의(x2=92.787,P=0.000).1225례족월인중존재염증면역과정적환인뇌손상적발생솔위13.0％(26/200),명현고우무명현염증면역과정자(7.5％,77/1025),차이유통계학의의(x2=6.544,P=0.011).Logistic회귀분석현시,중도감염시도치중도뇌손상적독립위험인소(OR=15.750,95％CI:1.756～141.281,P=0.014). 결론 신생인감염성질병가도치신경계통손상,우기시중도감염혹존재염증면역과정시발생솔경고；감염월중,뇌손상정도월중,우기시혼잡유질식화저혈당등기타인소시.
Objective To investigate the correlation between neonatal infectious disease and brain injury. Methods Clinical data of 1266 newborns with infectious diseases were collected from Peking University First Hospital from November 2005 to August 2010.The occurrence of brain injury was summarized.Related factors of brain injury caused by infection and the risk factors for severe brain injury were analyzed by Logistic regression model. Results Among the newborns with neonatal infectious diseases, the incidence of brain injury was 8.6％ (108/1266), including 101 (8.0％)mild cases and seven (0.6％) severe cases. The incidence of brain injury for the newborns with severe infectious diseases was higher than those with mild infectious diseases [38.7％(29/75) vs 6.7％(79/1191),x2=92.787,P=0.000].The incidence of brain injury for the newborns with obvious inflammatory reaction was significantly higher than those without [(13.0％(26/200) vs 7.5％ (77/1025),x2=6.544,P=0.011].Severe infection was independent risk factor for severe brain injury by Logistic regression model analysis (OR =15.750,95％ CI:1.756-141.281,P=0.014). Conclusions Iniectious diseases could cause injury on central nervous system,especially when there are severe infections or inflammatory reactions. The severer the infection,the severer the brain injury,especially when complicated by some factors such as asphyxia and hypoglycemia.
