CAJ | 학술논문

研究雌激素受体(ER)敲除小鼠脑内，ERa和ERβ在介导内侧杏仁核中白细胞介素1β(IL-1β)表达的作用。IL-1β表达有显著的性别差异，并且在ER敲除小鼠含量减少。细菌脂多糖(LPS)或卵巢切除能够促进野生型和ERβ敲除小鼠(BERKO)IL-1β表达，但对ERa敲除小鼠(ERKO)无作用。相似的是.外源性雌激素能抑制野生型和BERKO小鼠IL-1β表达，后者时间稍有延搁，但对ERKO IL-1β表达没有影响。结果表明，ERα是内侧杏仁核IL1β表达调节的重要机制，提示ERs可作为选择性靶基因治疗和预防神经功能失常。
연구자격소수체(ER)고제소서뇌내，ERa화ERβ재개도내측행인핵중백세포개소1β(IL-1β)표체적작용。IL-1β표체유현저적성별차이，병차재ER고제소서함량감소。세균지다당(LPS)혹란소절제능구촉진야생형화ERβ고제소서(BERKO)IL-1β표체，단대ERa고제소서(ERKO)무작용。상사적시.외원성자격소능억제야생형화BERKO소서IL-1β표체，후자시간초유연각，단대ERKO IL-1β표체몰유영향。결과표명，ERα시내측행인핵IL1β표체조절적중요궤제，제시ERs가작위선택성파기인치료화예방신경공능실상。
IL- 1β expression in the medial amygdaloid nucleus (McA) from ERs (estrogen receptors) knockout mice was carried out to determine the roles of ERα and ER β in mediating IL-1β expression in the brain. There was clear sex difference of 1L-1β expression in MeA and 1L-1β expression was reduced in ERs-knockout mice. Either LPS or ovariectomy could enhance IL-1β expression in both wild type (WT) and ERβ knockout mice (BERKO), but not in ERa knockout mice (ERKO). Similarly, exoge nous estrogen could inhibit I1-1β expression in McA both from WT and BERKO mice, with the later in a lagged manner, but not from ERKO. The results clearly establish that ERa is a critical mechanism for IL-1β expression in McA, implying for a selective targeting of ERs in the treatment and prevention of neural dysfunction.