CAJ | 학술논문

目的:探讨A型性格对中老年人肱动脉血管内皮功能的影响.方法:按照A型性格量表,从正常中老年人中筛选出 A型性格组和非A型性格组各60例,采用高频超声榆测肱动脉血流介导的血管扩张功能(FMD),其指标用肱动脉舒张内径的变化率(D%)表示;所有人选者均测量身高、体质量并计算体质量指数(BMI),测量收缩压(SBP)、舒张压(DBP),测定空腹血糖(FPG)、三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、一氧化氮(NO)、内皮素(ET)及血管紧张素Ⅱ(AngⅡ).结果:(1)A型性格组SBP、DBP明显高于非A型性格组(P＜0.05);2组FPG、TC、TG及LDL-C差别尤统计学意义(P＞0.05).(2)A型性格组较非A型性格组D%及NO明显降低;而AngⅡ及ET明显升高(均P＜0.05).(3)A型行为分值与AngⅡ、ET、SBP、DBP均呈正相关(P＜0.05或P＜0.01),与D%及NO呈负相关(P＜0.05).经多元线性逐步回归分析,AngⅡ是A型性格的独立危险因素.结论:肾素血管紧张素醛固酮系统的异常激活所导致的AngⅡ增高可能是A型性格巾老年人内皮功能异常的主要机制.
목적:탐토A형성격대중노년인굉동맥혈관내피공능적영향.방법:안조A형성격량표,종정상중노년인중사선출 A형성격조화비A형성격조각60례,채용고빈초성유측굉동맥혈류개도적혈관확장공능(FMD),기지표용굉동맥서장내경적변화솔(D%)표시;소유인선자균측량신고、체질량병계산체질량지수(BMI),측량수축압(SBP)、서장압(DBP),측정공복혈당(FPG)、삼선감유(TG)、총담고순(TC)、저밀도지단백담고순(LDL-C)、일양화담(NO)、내피소(ET)급혈관긴장소Ⅱ(AngⅡ).결과:(1)A형성격조SBP、DBP명현고우비A형성격조(P＜0.05);2조FPG、TC、TG급LDL-C차별우통계학의의(P＞0.05).(2)A형성격조교비A형성격조D%급NO명현강저;이AngⅡ급ET명현승고(균P＜0.05).(3)A형행위분치여AngⅡ、ET、SBP、DBP균정정상관(P＜0.05혹P＜0.01),여D%급NO정부상관(P＜0.05).경다원선성축보회귀분석,AngⅡ시A형성격적독립위험인소.결론:신소혈관긴장소철고동계통적이상격활소도치적AngⅡ증고가능시A형성격건노년인내피공능이상적주요궤제.
Objective: To investigate the effect of type-A character on endothelial function in the elderly. Methods:According to type-A character scale of Zhang Baiyuan, type-A character group and non-type-A character group were screened from the normal elderly, 60 eases for each respectively. Flow-mediated diastolic function of brachial artery was examined by high-frequency eehocardiography, which was reflected by diastolic inner diameter changing rate (D %). Other parameters included height, weight, body mass index (BMI), systolic and diastolic blood pressure (SBP and DBP), fasting blood glucose (FPG), triglyceride (TG), total cholesterol(TC), low-density lipoprotein-cholesterol (LDL-C), nitric oxide (NO), endothelin (ET)and angiotensin Ⅱ (AngⅡ). All of the parameters and the scores of type-A character were compared and analyzed between the two groups. ResultS:(1) The levels of SBP and DBP were significantly higher in type A character group than those of non-type A character group (P＜0.05). There were no significant differences in values of FPG, TC, TG and LDL-C between two groups (P＞0.05). (2) The values of D% and NO were significantly lower in type A character group than those of non-type-A character group (P＜0.05 ). The values of Ang Ⅱand ET were significantly higher in type-A character group than those of non-type-A group (P＜0.05 ). (3)Pearson correlation analysis indicated that the scores of type-A character were positively correlated with Ang Ⅱ, ET, SBP and DBP (P＜0.05, P＜0.01), but negatively correlated with D% and NO (P＜0.05). Multiple linear stepwise regression analysis showed that only Ang Ⅱwas an independent risk factor for type-A character. Conclusion:h was showed that the increased Ang Ⅱinduced by abnormal activation of reunin-angiotensin-aldosteerone system (RAAS)may be the main mechanism of endothelial dysfunction in the eldedy with type-A character.