CAJ | 학술논문

目的：探讨补肾化瘀法改善缺血性认知障碍作用机理。方法：采用电磁流量计、同位素标记微球法、碱羟胺比色法、放免法、多发性梗塞性痴呆(MID)大鼠模型，探讨补肾化瘀法增智作用机理。结果：补肾化瘀法显著增加模型鼠脑血流量(CBF)、海马和皮质局部血流量(rCBF)，提高海马和皮质乙酰胆碱(Ach)含量和神经肽精氨酸加压素(AVP)、生长抑素(SS)含量，降低血浆内皮素(ET)的含量，作用明显优于脑复康组（P＜0.05或P＜0.01)。结论：增加脑CBF，调节脑组织神经递质、神经肽为补肾化瘀法干预血管性痴呆(VaD)的作用机理之一。
목적：탐토보신화어법개선결혈성인지장애작용궤리。방법：채용전자류량계、동위소표기미구법、감간알비색법、방면법、다발성경새성치태(MID)대서모형，탐토보신화어법증지작용궤리。결과：보신화어법현저증가모형서뇌혈류량(CBF)、해마화피질국부혈류량(rCBF)，제고해마화피질을선담감(Ach)함량화신경태정안산가압소(AVP)、생장억소(SS)함량，강저혈장내피소(ET)적함량，작용명현우우뇌복강조（P＜0.05혹P＜0.01)。결론：증가뇌CBF，조절뇌조직신경체질、신경태위보신화어법간예혈관성치태(VaD)적작용궤리지일。
Objective to study to the raputic mechanism of principle of tonifying the kidney and removing blood stasis for ischemia agnosia.Methods:model rats with MID were treated on above principle and detected with electromagnetic flowmeter and micropellet-isotope label method,and neurous mediae (Ach,Avp.SS) and neuropepide(ET) with alkaline hydromine colorimetric method and radioimmunoassay(RIA)respectively.Results:levels of CBF,r CBF,Ach,Avp and SS ascend in brain,while level of ET descend in serum(P＜0.01 or P＜0.05).Conclusion:the results suggest that it may be a part of the mechanism of the principle in treatment of vascular dementia to increase CBF,adjust nervous mediae and nervous peptide.