CAJ | 학술논문

小鼠nepmucin是一种新型黏附分子,胞外区含有一个典型的粘蛋白样结构域和一个V型免疫球蛋白(Ig)结构域,广泛表达于除派氏结(PPs)外的外周淋巴组织和实质性器官.优先表达于各种组织的小血管内皮细胞.该分子可与淋巴细胞归巢的重要分子L-选择素(L-selectin)结合,分别通过粘蛋白样结构域和Ig结构域介导L-selectin依赖的淋巴细胞在血管内皮上的滚动、附着,促进淋巴细胞穿 .越(TEM)高内皮微静脉(HEV)内皮细胞.小鼠nepmucin与CD31分子在淋巴结HEV内皮细胞的分布相似,且同样发生循环,但其循环机制以及分子循环所发挥的生物学作用尚不清楚.
소서nepmucin시일충신형점부분자,포외구함유일개전형적점단백양결구역화일개V형면역구단백(Ig)결구역,엄범표체우제파씨결(PPs)외적외주림파조직화실질성기관.우선표체우각충조직적소혈관내피세포.해분자가여림파세포귀소적중요분자L-선택소(L-selectin)결합,분별통과점단백양결구역화Ig결구역개도L-selectin의뢰적림파세포재혈관내피상적곤동、부착,촉진림파세포천 .월(TEM)고내피미정맥(HEV)내피세포.소서nepmucin여CD31분자재림파결HEV내피세포적분포상사,차동양발생순배,단기순배궤제이급분자순배소발휘적생물학작용상불청초.
Mouse nepmucin,an adhesion molecule containing a classical mucin-like domain and a V-type Ig domain,is expressed extensively in small vascular endothelial cells of peripheral lymph tissues and parenchymatous organs,but not in Peyer's patches(PPs).Nepmucin can bind to L-selectin,a crucial molecule for lymphocyte homing,and mediate L-selectln-depedent lymphoeyte rolling,adhesion,and promote transendothelial migration(TEM) via its mucin-like domain and Ig domain.Mouse nepmucin shows similar distribution and recycling feature as CD31 molecule On HEV endothelial cells in lymph nodes.However,the mechanism and biological functions of the recycling of this molecule remain unclear.