CAJ | 학술논문

目的比较雾化吸入布地奈德混悬液与吸人布地奈德气雾剂治疗婴幼儿哮喘的疗效.方法将80例年龄小于3岁的哮喘患几随机分为三组,A组(20例)用雾化器吸人布地奈德混悬液;B组(30例)使用面罩型筒式贮雾罐吸入布地奈德气雾剂;对照组(30例)不用吸入激素,常规治疗.在观察期的第1、3、6、12个月复诊,比较三组的临床症状评分、哮喘急性发作及药物使用的情况.结果与对照组相比,A组和B组日间、夜间症状评分明显降低(P<0.01),哮喘的急性发作显著减少,使用β2受体激动剂和全身激素的次数减少(P<0.01);而A组在观察期的第1、3、6个月的治疗效果比B组更明显(P<0.05),两组在第12个月的治疗指标的差异无统计学意义(P>0.05).结论吸入布地奈德治疗可使哮喘得到长期的缓解;使用雾化器吸入布地奈德混悬液,可以更早、更好地减轻哮喘症状,是婴幼儿哮喘的首选吸入方式.
목적 비교무화흡입포지내덕혼현액여흡인포지내덕기무제치료영유인효천적료효.방법 장80례년령소우3세적효천환궤수궤분위삼조,A조(20례)용무화기흡인포지내덕혼현액;B조(30례)사용면조형통식저무관흡입포지내덕기무제;대조조(30례)불용흡입격소,상규치료.재관찰기적제1、3、6、12개월복진,비교삼조적림상증상평분、효천급성발작급약물사용적정황.결과 여대조조상비,A조화B조일간、야간증상평분명현강저(P<0.01),효천적급성발작현저감소,사용β2수체격동제화전신격소적차수감소(P<0.01);이A조재관찰기적제1、3、6개월적치료효과비B조경명현(P<0.05),량조재제12개월적치료지표적차이무통계학의의(P>0.05).결론 흡입포지내덕치료가사효천득도장기적완해;사용무화기흡입포지내덕혼현액,가이경조、경호지감경효천증상,시영유인효천적수선흡입방식.
Objective To evaluate the efficacy of inhalation of budesonide bitween suspension and aerosol in the treatment of infant asthma. Methods 80 patients less than 3 years old were divided in three groups randomly,in group A the patients received budesonide suspension inhalation therapy,in group B the patients received budesonide aeroso inhalation therapy, in group C the patients received route treament. The patients were followed 1,3,6,12 months after teeament,symptom assessment scores, acute episode of asthma and administration of medication were compared beteen two groups. Results Compared with group C, symptom assessment scores became lower (P <0.01 ) ,acute episode of asthma reduced and use of receptor β2 receptor agonist and steroid reduced in group A and B(P<0.01);after 1,3,6 montha, the indicators observed in group A was better than in group B(P< 0.05),but there was no difference between two group after 12 months( P > 0.05). Conclusion Budesonide inhalaton is effec-tire in the treatment of asthma, in patients with infant asthma, budesonide suspension aerosol inhalation should be the first choice of treatment.