CAJ | 학술논문

目的探讨由羟基磷灰石和左旋聚乳酸复合研制的新型生物活性颈椎椎间融合器在颈椎融合术中不同固定方式的生物力学特性.方法制备新鲜人颈椎标本6个(尸体均为合法捐赠,由南方医科大学解剖学教研室提供),模拟临床术式行前路C5～6减压椎间分别植入髂骨、生物活性颈椎椎间融合器和生物活性颈椎椎间融合器加钢板内固定,通过脊柱三维运动实验机测量C5～6节段的运动范围.结果生物活性颈椎椎间融合器加钢板固定后稳定性增加,在各个状态的运动范围均明显小于其他各组(P ＜0.005).单纯生物活性颈椎椎间融合器组在后伸状态下运动范围(6.25±0.29)度较正常组(5.76±0.40)度增大,稳定性下降,但差异无统计学意义(P＞0.05)；在除后伸外的其他各种状态下的运动范围均小于髂骨组,较髂骨组稳定,差异有统计学意义(P＜0.005).结论新型生物活性颈椎椎间融合器具有良好的生物力学性能,加钢板内固定后各个方向稳定性好,能重建颈椎稳定性.
목적 탐토유간기린회석화좌선취유산복합연제적신형생물활성경추추간융합기재경추융합술중불동고정방식적생물역학특성.방법 제비신선인경추표본6개(시체균위합법연증,유남방의과대학해부학교연실제공),모의림상술식행전로C5～6감압추간분별식입가골、생물활성경추추간융합기화생물활성경추추간융합기가강판내고정,통과척주삼유운동실험궤측량C5～6절단적운동범위.결과 생물활성경추추간융합기가강판고정후은정성증가,재각개상태적운동범위균명현소우기타각조(P ＜0.005).단순생물활성경추추간융합기조재후신상태하운동범위(6.25±0.29)도교정상조(5.76±0.40)도증대,은정성하강,단차이무통계학의의(P＞0.05)；재제후신외적기타각충상태하적운동범위균소우가골조,교가골조은정,차이유통계학의의(P＜0.005).결론 신형생물활성경추추간융합기구유량호적생물역학성능,가강판내고정후각개방향은정성호,능중건경추은정성.
Objective To investigate the biomechanical characteristics of different types of fixation with bioactive cervical fusion cage made of hydroxyapatite and poly L-lactic acid in cervical spinal fusion.Methods Iliac crest bone,bioactive cervical fusion cage and bioactive cervical fusion cage with plate fixation were used for anterior interbody implants after anterior discectomy across C5-6 in six fresh human cervical spine specimens respectively,and the range of motion of the cervical vertebrae interbody fusion were measured through the motional stability test.Results After discectomy,Bioactive Cervical Fusion Cage with plate fixation exhibited a significant increase in stability and a decrease of range of motion in angular motion than others in all motional directions ( P ＜ 0.005 ). Bioactive cervical fusion cage exhibited a decrease in stability and an increase of range of motion (6.25 ± 0.29) in angular motion than the intact spine (5.76 ± 0.40) in extension,but the difference was not significantly ( P ＞ 0.05 ).Bioactive cervical fusion cage exhibited a decrease in angular motion than iliac crest bone and a significant increase in stability in all motional directions except extension (P ＜ 0.005).Conclusions Bioactive cervical fusion cage' s biomechanical performance was excellent and bioactive cervical fusion cage with plate fixation was excellent in stability in all motional direction,and could remain initial stability of cervical vertebrae.