CAJ | 학술논문

目的探讨国内慢性胰腺炎(CP)患者烟酒摄入量与发生胰腺钙化间的关系.方法按入院时有无胰腺钙化分为两组进行比较分析,再将无胰腺钙化者出院后有无新发胰腺钙化分为新发组和持续无钙化组.Logistic回归或Cox比例风险模型进行逐步回归分析胰腺钙化的风险因素.结果 1997年1月到2007年7月共收治并成功随访449例CP患者,248例有胰腺钙化;201例无胰腺钙化,其中13例出院后新发生胰腺钙化.入院时胰腺钙化者的发病年龄小、病史长、糖尿病和腹泻发生率高.首发年龄≤40岁、酒精摄入量>20 g/d、糖尿病和腹泻为胰腺钙化风险因素;过量饮酒为无胰腺钙化CP 患者新发生钙化的唯一风险因素(OR 3.2).结论饮酒增加CP患者胰腺钙化风险,建议戒酒;吸烟的作用需进一步研究.
목적 탐토국내만성이선염(CP)환자연주섭입량여발생이선개화간적관계.방법 안입원시유무이선개화분위량조진행비교분석,재장무이선개화자출원후유무신발이선개화분위신발조화지속무개화조.Logistic회귀혹Cox비례풍험모형진행축보회귀분석이선개화적풍험인소.결과 1997년1월도2007년7월공수치병성공수방449례CP환자,248례유이선개화;201례무이선개화,기중13례출원후신발생이선개화.입원시이선개화자적발병년령소、병사장、당뇨병화복사발생솔고.수발년령≤40세、주정섭입량>20 g/d、당뇨병화복사위이선개화풍험인소;과량음주위무이선개화CP 환자신발생개화적유일풍험인소(OR 3.2).결론 음주증가CP환자이선개화풍험,건의계주;흡연적작용수진일보연구.
Objective To investigate the relationship between alcohol and smoking and the development of pancreatic calcification in chronic pancreatitis (CP) in China. Methods The patients were divided into two groups according to the presence of pancreatic calcification at admission and the data were analyzed; furthermore, the discharged patients without pancreatic calcification were divided into two groups as newly diagnosed pancreatic calcification group and persistent non-pancreatic calcification group. Logistic regression and Cox proportional-hazards model was used for multivariate analysis of the risk factors for pancreatic calcification. Results From January1997 to July 2007, 449 patients with CP were enrolled and followed up successfully. 248 patients presented with pancreatic calcification at admission; among the 201 patients presented without pancreatic calcification, 13 patients developed pancreatic calcification after discharge. Patients with pancreatic calcification had a young age at onset, long CP history, higher incidence of diabetes mellitus and diarrhea. Age at onset ≤ 40, alcohol intake over 20 g/day, and diabetes mellitus and diarrhea were risk factors for pancreatic calcification. The only risk factor of development of pancreatic calcification after discharge was excessive alcohol intake (OR: 3.2). Conclusions Alcohol intake increased the risk of pancreatic calcifications, suggesting the patients abstain from alcohol intake. Further studies are necessary to clarify the role of smoking.