CAJ | 학술논문

目的探索蛋白酪氨酸磷酸酶与肺癌组织学类型的关系。方法用免疫组织化学技术(LSAB法)检测肺良性病变和肺癌组织中蛋白酪氨酸磷酸酶的表达。结果蛋白酪氨酸磷酸酶阳性率在34例肺良性病变的支气管粘膜上皮细胞为95.03％±2.10％，121例肺癌为43.59％±14.41％；46例腺癌为47.57％±16.26％，48例鳞癌为40.59％±14.04％，27例腺鳞癌为42.13％±9.84％；21例低分化鳞癌为31.63％±10.34％，18例中分化鳞癌为41.39％±9.35％，9例高分化鳞癌为59.90％±8.61％；16例低分化腺癌为 34.14％±12.53％，26例中分化腺癌为52.10％±12.19％，4例高分化腺癌为63.05％±15.84％。蛋白酪氨酸磷酸酶阳性率在肺良性病变与肺癌间，以及低分化肺癌与高分化肺癌间的差异有显著性(P＜0.01或P＜0.05)。结论检测蛋白酪氨酸磷酸酶有助于鉴别肺部的良恶性疾病，并可能作为预测肺癌预后的指标之一。
목적탐색단백락안산린산매여폐암조직학류형적관계。방법용면역조직화학기술(LSAB법)검측폐량성병변화폐암조직중단백락안산린산매적표체。결과단백락안산린산매양성솔재34례폐량성병변적지기관점막상피세포위95.03％±2.10％，121례폐암위43.59％±14.41％；46례선암위47.57％±16.26％，48례린암위40.59％±14.04％，27례선린암위42.13％±9.84％；21례저분화린암위31.63％±10.34％，18례중분화린암위41.39％±9.35％，9례고분화린암위59.90％±8.61％；16례저분화선암위 34.14％±12.53％，26례중분화선암위52.10％±12.19％，4례고분화선암위63.05％±15.84％。단백락안산린산매양성솔재폐량성병변여폐암간，이급저분화폐암여고분화폐암간적차이유현저성(P＜0.01혹P＜0.05)。결론검측단백락안산린산매유조우감별폐부적량악성질병，병가능작위예측폐암예후적지표지일。
Objective　To investigate the relationship between histological classification of lung cancer and protein tyrosine phosphatase. Methods　The expression of protein tyrosine phosphatase in bronchial epithelia from 34 patients with benign pulmonary lesions and 121 patients with primary pulmonary carcinoma was examined by immunohistochemical staining method. Results　The positive rate of protein tyrosine phosphatase expression was 95.03％±2.10％ in 34 patients with benign pulmonary lesions, 43.59％±14.41％ in 121 patients with primary pulmonary carcinoma; 47.57％±16.26％ in 46 patients with adenocarcinoma, 40.59％±14.04％ in 48 patients with squamous cell carcinoma, 42.13％±9.84％ in 27 patients with adenosquamous carcinoma; 31.63％±10.34％ in 21 patients with poor differentiated squamous cell carcinoma, 41.39％±9.35％ in 18 patients with intermediate differentiated squamous cell carcinoma, 59.90％±8.61％ in 9 patients with well differentiated squamous cell carcinoma; 34.14％±12.53％ in 16 patients with poor differentiated adenocarcinoma, 52.10％±12.19％ in 26 patients with intermediate differentiated adenocarcinoma, and 63.05％±15.84％ in 4 patients with well differentiated adenocarcinoma. A significant difference of protein tyrosine phosphatase positive expression was observed between benign pulmonary lesions and primary pulmonary carcinomas, and between poor differentiated primary pulmonary carcinomas and well differentiated primary pulmonary carcinomas (P＜0.01 or P＜0.05). Conclusion　Detection of protein tyrosine phosphatase may be helpful to differentiate pulmonary lesions from lung cancer and be regarded as one of the indices in predicting the prognosis of patients with primary pulmonary carcinomas.