CAJ | 학술논문

背景:目前,中药已广泛运用于对恶性肿瘤治疗上,探讨和总结不同中药疗法对恶性肿瘤化疗增效作用,已成为中药研究的热点之一.目的:研究中药加味当归补血汤对肿瘤化疗的增效作用.设计:采取随机分组原则,建立不同中药剂量实验观察组及单纯西药组和对照组.地点与材料:以成都军区总医院中心实验室为实验地点,采用ICR小鼠作为实验动物.干预:将小鼠复制成荷肝癌实体瘤、S180肉瘤实验模型,并分别或联合给与加味当归补血汤与环磷酰胺.主要观察指标:观察不同剂量加味当归补血汤与环磷酰胺联用对肿瘤的抑制率以及小鼠生存期的影响.结果:加味当归补血汤与环磷酰胺联用,对小鼠肝癌实体瘤及S180肉瘤的抑制有协同增效作用,环磷酰胺加高剂量加味当归补血汤组瘤体平均质量明显低于环磷酰胺组,分别为(1.52±1.12)g,(0.32±0.22)g,差异有非常显著性意义(P＜0.01);对艾氏腹水癌和肝癌腹水型能明显延长小鼠生存期,环磷酰胺加高剂量加味当归补血汤组,其生存期达(31.56±4.02)d,(32.16±3.66)d,与环磷酰胺对照组比较,差异具有非常显著性意义(P＜0.01).结论:加味当归补血汤能显著提高肿瘤化疗的疗效,在肿瘤的化疗中,具有一定的协同增效作用.
배경:목전,중약이엄범운용우대악성종류치료상,탐토화총결불동중약요법대악성종류화료증효작용,이성위중약연구적열점지일.목적:연구중약가미당귀보혈탕대종류화료적증효작용.설계:채취수궤분조원칙,건립불동중약제량실험관찰조급단순서약조화대조조.지점여재료:이성도군구총의원중심실험실위실험지점,채용ICR소서작위실험동물.간예:장소서복제성하간암실체류、S180육류실험모형,병분별혹연합급여가미당귀보혈탕여배린선알.주요관찰지표:관찰불동제량가미당귀보혈탕여배린선알련용대종류적억제솔이급소서생존기적영향.결과:가미당귀보혈탕여배린선알련용,대소서간암실체류급S180육류적억제유협동증효작용,배린선알가고제량가미당귀보혈탕조류체평균질량명현저우배린선알조,분별위(1.52±1.12)g,(0.32±0.22)g,차이유비상현저성의의(P＜0.01);대애씨복수암화간암복수형능명현연장소서생존기,배린선알가고제량가미당귀보혈탕조,기생존기체(31.56±4.02)d,(32.16±3.66)d,여배린선알대조조비교,차이구유비상현저성의의(P＜0.01).결론:가미당귀보혈탕능현저제고종류화료적료효,재종류적화료중,구유일정적협동증효작용.
BACKGROUND: Traditional Chinese medical herbs have been widely used in the treatment of malignant tumor; thereby investigations and results on the synergisms of different prescriptions to chemotherapy are warmly discussed.OBJECTIVE: To explore the synergisms of jiawei danggui buxue decoction on the chemotherapy of cancer.DESIGN: Mice were randomly divided into experiment groups intervened by both cyclophosphamide (CPA) and the traditional Chinese medical prescription of different dosages, group intervened by CPA only and control group.SETTING and MATERIALS: The experiment was completed in the Central Laboratory of General Hospital of Chengdu Military Region. ICR mice were adopted for experiment.INTERVENTIONS: Models of mice with liver cancer or S180 sarcoma were set up, and subsequently given with CPA, or both CPA and jiawei danggui buxue decoction.MAIN OUTCOME MEASURES: The inhibition rate of cancer intervened by CPA with jiawei danggui buxue decoction of different dosage, and the survival time changes of mice.RESULTS: CPA and jiawei danggui buxue decoction affected a synergism for liver cancer and S180 sarcoma of mouse models; the average mass of liver cancer was significantly reduced in mice given with CPA with jiawei danggui buxue decoction of higher dosage, compared with that given with CPA only[(1.52 ± 1.12)g vs (0.32±0.22)g](P ＜0.01);as for survival time of mice with Ai' ascitic cancer and liver cancer of ascitic type could be obviously prolonged by CPA combined with jiawei danggui buxue decoction of higher dosage [ ( 31.56 ± 4.02 ) days and ( 32. 16 ± 3.66 ) days respectively], statistically different from that by CPA only( P ＜ 0.01).CONCLUSION: Jiawei danggui buxue decoction could obviously improve the therapeutic effect, and affect a synergism to the chemotherapy for cancer.