CAJ | 학술논문

通过研究对苯二甲酸（TPA）在大鼠的毒代动力学，为制定生物接触限值(BEI)提供依据。选清洁级SD大鼠8只，一次性灌胃染毒100mg/kgBWTPA后，采用反相高效液相色谱法测定尿TPA浓度，用3P97计算毒代动力学参数。结果显示，TPA在体内的毒代动力学行为符合一级吸收二室模型，吸收速率常数ka为0.51/h，吸收相半衰期t1/2ka=0.488h，分布相半衰期t1/2d为2.446h,达峰时间tpeak为2.16h，消除速率常数Ku为0.143/h，消除相半衰期t1/2β为31.551h，TPA经尿排泄累积量为10.00mg，24h内约50%的TPA由尿排泄，48h内约52%，72h内约53%以上的TPA由尿排泄。结论：TPA在体内吸收快、消除快，主要以原形由尿排泄，提示职业人群的工后尿TPA可作为接触性生物标志物。
통과연구대분이갑산（TPA）재대서적독대동역학，위제정생물접촉한치(BEI)제공의거。선청길급SD대서8지，일차성관위염독100mg/kgBWTPA후，채용반상고효액상색보법측정뇨TPA농도，용3P97계산독대동역학삼수。결과현시，TPA재체내적독대동역학행위부합일급흡수이실모형，흡수속솔상수ka위0.51/h，흡수상반쇠기t1/2ka=0.488h，분포상반쇠기t1/2d위2.446h,체봉시간tpeak위2.16h，소제속솔상수Ku위0.143/h，소제상반쇠기t1/2β위31.551h，TPA경뇨배설루적량위10.00mg，24h내약50%적TPA유뇨배설，48h내약52%，72h내약53%이상적TPA유뇨배설。결론：TPA재체내흡수쾌、소제쾌，주요이원형유뇨배설，제시직업인군적공후뇨TPA가작위접촉성생물표지물。
In order to study the toxicokinetics of terephthalic acid(TPA) inrats, and provide scientific basis for its biological exposed index(BEI), the concentrations of urine TPA in rats after single oral administration in dose of 100mg/kgBW were determined by high pressure liquid chromatography. The toxicokinetic parameters were computed by using 3P97 program. The results showed that the first-order kinetics and two-compartment model were noted on the elimination of TPA . The main toxicokinetic parameters were as follows: Ka=0.51/h, T1/2ka=0.488h, T1/2α=2.446h ,Tpeak =2.160h, Ku=0.143/h，T1/2β=31.551h, Xu(max)= 10.00mg. The excretion rates of TPA in urine were about 50%, 52% and 53% in 0～24h, 0～48h and 0～72 h respectively after administration. TPA is well absorbed when given orally and rapidly eliminated via urine. Urine TPA at the end of work shift should be considered as a biomarker of exposure for the occupational workers.