CAJ | 학술논문

目的观察急性缺血性卒中患者发病后早期血浆超敏c反应蛋白(high sensitive C-reactive protein,hs-CRP)及白介素-6 (interleukin-6,IL-6)水平的动态变化规律,探讨其与卒中患者临床表现及预后的关系.方法:连续入选急性缺血性卒中患者47例,正常对照组40例,比较卒中组发病后系列时间点血浆hs-CRP和IL-6水平与正常对照组之间的差异,分析其动态变化规律;按照基线美国国立卫生研究院卒中量表(national institutes of health stroke scale,NIHSS)评分将患者分为轻型组(n=15)和重型组(n=32),比较两组血浆hs-CRP和IL-6水平;并比较不同临床预后患者血浆hs-CRP和IL-6水平的差异.结果:卒中组发病3h时血桨hs-CRP较对照组差异无统计学意义,6h、12h、24h、48h、3d及7d血浆hs-CRP较对照组明显升高(均P<0.01).卒中组各时间点血浆IL-6水平均高于正常对照组(均PG0.01).重型组血浆hs-CRP水平在12h、24h、48h、3d及7d时水平均高于轻型组(P=0.046,0.012,0.030,0.007,0.041);重型组血浆IL-6水平在12h、24h、48h、3d及7d时水平均高于轻型组(P=0.002,0.001,0.006,0.026,0.043).不同预后组之间血浆hs-CRP和IL-6水平差异不明显.结论:急性缺血性卒中患者血浆hs-CRP和IL-6水平升高,且与临床严重程度有关.
목적 관찰급성결혈성졸중환자발병후조기혈장초민c반응단백(high sensitive C-reactive protein,hs-CRP)급백개소-6 (interleukin-6,IL-6)수평적동태변화규률,탐토기여졸중환자림상표현급예후적관계.방법:련속입선급성결혈성졸중환자47례,정상대조조40례,비교졸중조발병후계렬시간점혈장hs-CRP화IL-6수평여정상대조조지간적차이,분석기동태변화규률;안조기선미국국립위생연구원졸중량표(national institutes of health stroke scale,NIHSS)평분장환자분위경형조(n=15)화중형조(n=32),비교량조혈장hs-CRP화IL-6수평;병비교불동림상예후환자혈장hs-CRP화IL-6수평적차이.결과:졸중조발병3h시혈장hs-CRP교대조조차이무통계학의의,6h、12h、24h、48h、3d급7d혈장hs-CRP교대조조명현승고(균P<0.01).졸중조각시간점혈장IL-6수평균고우정상대조조(균PG0.01).중형조혈장hs-CRP수평재12h、24h、48h、3d급7d시수평균고우경형조(P=0.046,0.012,0.030,0.007,0.041);중형조혈장IL-6수평재12h、24h、48h、3d급7d시수평균고우경형조(P=0.002,0.001,0.006,0.026,0.043).불동예후조지간혈장hs-CRP화IL-6수평차이불명현.결론:급성결혈성졸중환자혈장hs-CRP화IL-6수평승고,차여림상엄중정도유관.