国际免疫学杂志
國際免疫學雜誌
국제면역학잡지
INTERNATIONAL JOURNAL OF IMMUNOLOGY
2010年
1期
1-4,30
,共5页
microRNAs%癌基因%抑癌基因%肿瘤
microRNAs%癌基因%抑癌基因%腫瘤
microRNAs%암기인%억암기인%종류
microRNAs%Oncogene%Tumor suppressor gene%Tumor
microRNAs是一类新型保守的微小非编码单链RNA,成熟的microRNAs通过与靶基因mRNA碱基形成不完全配对,引起mRNA降解及转录抑制.研究表明,microRNAs对细胞增殖、细胞分化和细胞凋亡具有重要的调控作用,microRNAs的表达异常与肿瘤的发生发展密切相关,肿瘤中既存在肿瘤抑制作用的microRNAs,也存在肿瘤促进作用的microRNAs.因此,microRNAs分子虽小,却在肿瘤发生、发展的过程中作用重大.
microRNAs是一類新型保守的微小非編碼單鏈RNA,成熟的microRNAs通過與靶基因mRNA堿基形成不完全配對,引起mRNA降解及轉錄抑製.研究錶明,microRNAs對細胞增殖、細胞分化和細胞凋亡具有重要的調控作用,microRNAs的錶達異常與腫瘤的髮生髮展密切相關,腫瘤中既存在腫瘤抑製作用的microRNAs,也存在腫瘤促進作用的microRNAs.因此,microRNAs分子雖小,卻在腫瘤髮生、髮展的過程中作用重大.
microRNAs시일류신형보수적미소비편마단련RNA,성숙적microRNAs통과여파기인mRNA감기형성불완전배대,인기mRNA강해급전록억제.연구표명,microRNAs대세포증식、세포분화화세포조망구유중요적조공작용,microRNAs적표체이상여종류적발생발전밀절상관,종류중기존재종류억제작용적microRNAs,야존재종류촉진작용적microRNAs.인차,microRNAs분자수소,각재종류발생、발전적과정중작용중대.
microRNAs are a new/class of small, evolutionarily conserved, non-protein-coding RNA molecules. Mature microRNAs exert their gene regulatory activity primarily by imperfectly base pairing to their target mRNAs, leading to mRNA degradation or translational inhibition. Recent studies have verified that microRNAs play a key role in diverse biological processes, including cell proliferation and differentiation as well as apoptosis. Further studies showed that microRNAs as oncogenes and tumor suppressors are involved in the tumor formation and development. Accordingly, microRNAs as a kind of small RNA molecules play an important role in tumorigenesis.
