目的 分析军事飞行员血清载脂蛋白谱的特征及其与血脂的关系. 方法 随机抽取进行疗养的男性飞行员180名,平均年龄35.9±7.5岁,为其进行体检并测定血清载脂蛋白(apo)A1、A2、B、C2、C3、E以及三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)和低密度脂蛋白胆固醇(LDL-C). 结果 ①血清apoA2、apoB、apoC3和apoE水平随年龄增加而显著升高;②与无脂代谢紊乱的飞行员相比较,高TG血症者的apoB(0.920±0.237 vs 0.789±0.207 g/L,t=-2.875,P=0.005)、apoC2(0.066±0.016 vs 0.039±0.015 g/L,t=-8.151,P=0.000)、apoC3(0.169±0.054 vs 0.108±0.028 g/L,t=-5.611,P=0.000)和apoE(0.056±0.011 vs 0.043±0.009 g/L,t=-6.408,P=0.000)水平显著升高,而apoA1(1.309±0.143 vs 1.421±0.213 g/L,t=2.586,P=0.011)的水平降低;高TC或伴高TG血症者的所有载脂蛋白水平均升高;低HDL-C血症者的apoA1(1.096±0.166 vs 1.421±0.213 g/L,t=6.754,P=0.000)和apoA2(0.252±0.028 vs 0.292士0.041 g/L,t=3.557,P=0.001)水平降低,而apoC2(0.187±0.069 vs 0.039±0.015 g/L,t=-3.513,P=0.000)、apoC3(0.169±0.064 vs 0.108±0.028 g/L,t=-4.176,P=0.001)和apoE(0.054±0.028 vs 0.043±0.009 g/L,t=-3.177,P=0.002)水平显著升高;③血清TC与所有载脂蛋白呈正相关;TG与apoB(r=0.349,P＜0.01)、apoC2(r=0.517,P＜0.01)、apoC3(r=0.746,P＜0.01)和apoE(r=0.621,P＜0.01)呈正相关;HDL-C与apoAl(r=0.873,P＜0.01)和apoA2(r=0.494,P＜0.01)呈正相关,与apoC2(r=-0.152,P＜0.05)呈负相关;LDL-C与apoA2(r=0.295,P＜0.01)、apoB(r=0.864,P＜0.01)和apoE(r=0.273,P＜0.01)呈正相关. 结论 180名男性飞行员的血清apoA2、apoB、apoC3和apoE水平与年龄增加有关,多种载脂蛋白的水平与血脂异常密切相关.
目的 分析軍事飛行員血清載脂蛋白譜的特徵及其與血脂的關繫. 方法 隨機抽取進行療養的男性飛行員180名,平均年齡35.9±7.5歲,為其進行體檢併測定血清載脂蛋白(apo)A1、A2、B、C2、C3、E以及三酰甘油(TG)、總膽固醇(TC)、高密度脂蛋白膽固醇(HDL-C)和低密度脂蛋白膽固醇(LDL-C). 結果 ①血清apoA2、apoB、apoC3和apoE水平隨年齡增加而顯著升高;②與無脂代謝紊亂的飛行員相比較,高TG血癥者的apoB(0.920±0.237 vs 0.789±0.207 g/L,t=-2.875,P=0.005)、apoC2(0.066±0.016 vs 0.039±0.015 g/L,t=-8.151,P=0.000)、apoC3(0.169±0.054 vs 0.108±0.028 g/L,t=-5.611,P=0.000)和apoE(0.056±0.011 vs 0.043±0.009 g/L,t=-6.408,P=0.000)水平顯著升高,而apoA1(1.309±0.143 vs 1.421±0.213 g/L,t=2.586,P=0.011)的水平降低;高TC或伴高TG血癥者的所有載脂蛋白水平均升高;低HDL-C血癥者的apoA1(1.096±0.166 vs 1.421±0.213 g/L,t=6.754,P=0.000)和apoA2(0.252±0.028 vs 0.292士0.041 g/L,t=3.557,P=0.001)水平降低,而apoC2(0.187±0.069 vs 0.039±0.015 g/L,t=-3.513,P=0.000)、apoC3(0.169±0.064 vs 0.108±0.028 g/L,t=-4.176,P=0.001)和apoE(0.054±0.028 vs 0.043±0.009 g/L,t=-3.177,P=0.002)水平顯著升高;③血清TC與所有載脂蛋白呈正相關;TG與apoB(r=0.349,P＜0.01)、apoC2(r=0.517,P＜0.01)、apoC3(r=0.746,P＜0.01)和apoE(r=0.621,P＜0.01)呈正相關;HDL-C與apoAl(r=0.873,P＜0.01)和apoA2(r=0.494,P＜0.01)呈正相關,與apoC2(r=-0.152,P＜0.05)呈負相關;LDL-C與apoA2(r=0.295,P＜0.01)、apoB(r=0.864,P＜0.01)和apoE(r=0.273,P＜0.01)呈正相關. 結論 180名男性飛行員的血清apoA2、apoB、apoC3和apoE水平與年齡增加有關,多種載脂蛋白的水平與血脂異常密切相關.
목적 분석군사비행원혈청재지단백보적특정급기여혈지적관계. 방법 수궤추취진행요양적남성비행원180명,평균년령35.9±7.5세,위기진행체검병측정혈청재지단백(apo)A1、A2、B、C2、C3、E이급삼선감유(TG)、총담고순(TC)、고밀도지단백담고순(HDL-C)화저밀도지단백담고순(LDL-C). 결과 ①혈청apoA2、apoB、apoC3화apoE수평수년령증가이현저승고;②여무지대사문란적비행원상비교,고TG혈증자적apoB(0.920±0.237 vs 0.789±0.207 g/L,t=-2.875,P=0.005)、apoC2(0.066±0.016 vs 0.039±0.015 g/L,t=-8.151,P=0.000)、apoC3(0.169±0.054 vs 0.108±0.028 g/L,t=-5.611,P=0.000)화apoE(0.056±0.011 vs 0.043±0.009 g/L,t=-6.408,P=0.000)수평현저승고,이apoA1(1.309±0.143 vs 1.421±0.213 g/L,t=2.586,P=0.011)적수평강저;고TC혹반고TG혈증자적소유재지단백수평균승고;저HDL-C혈증자적apoA1(1.096±0.166 vs 1.421±0.213 g/L,t=6.754,P=0.000)화apoA2(0.252±0.028 vs 0.292사0.041 g/L,t=3.557,P=0.001)수평강저,이apoC2(0.187±0.069 vs 0.039±0.015 g/L,t=-3.513,P=0.000)、apoC3(0.169±0.064 vs 0.108±0.028 g/L,t=-4.176,P=0.001)화apoE(0.054±0.028 vs 0.043±0.009 g/L,t=-3.177,P=0.002)수평현저승고;③혈청TC여소유재지단백정정상관;TG여apoB(r=0.349,P＜0.01)、apoC2(r=0.517,P＜0.01)、apoC3(r=0.746,P＜0.01)화apoE(r=0.621,P＜0.01)정정상관;HDL-C여apoAl(r=0.873,P＜0.01)화apoA2(r=0.494,P＜0.01)정정상관,여apoC2(r=-0.152,P＜0.05)정부상관;LDL-C여apoA2(r=0.295,P＜0.01)、apoB(r=0.864,P＜0.01)화apoE(r=0.273,P＜0.01)정정상관. 결론 180명남성비행원적혈청apoA2、apoB、apoC3화apoE수평여년령증가유관,다충재지단백적수평여혈지이상밀절상관.
Objective To explore the characteristics of serum lipid and apolipoprotein profile in military pilots, and to better understand the associations between apolipoproteins with lipids.Methods The present study was performed in 180 male military pilots who were recruited randomly.They all underwent a physical examination and their serum apolipoprotein (apo) A1, A2, B, C2, C3,0. 237 vs 0. 789±0. 207 g/L, t=-2. 875, P=0. 005), apoC2 (0. 066±0. 016 vs 0. 039±0. 015 g/L,t=-8.151,P=0.000), apoC3 (0.169±0.054 vs 0.108±0.028 g/L, t=-5.611, P=0.000) and apoE (0. 056±0. 011 vs 0. 043±0. 009 g/L, t=-6.408, P=0.000) increased, while apoA1 (1.309±0.143 vs 1.421±0.213 g/L, t=2.586, P=0.011) decreased in the hypertriglyceridemias, all apos increased in hypercholesteremias or combined hypertriglyceridemias (P＜0.01 ), apoA1 (1.096±0.166 vs 1.421±0.213 g/L, t=6.754, P=0.000), apoA2 (0.252±0.028 vs 0.292±0.041 g/L,t=3.557, P=0.001) decreased and apoC2 (0.187±0.069 vs 0.039±0.015 g/L, t=-3.513, P=0.000), apoC3 (0.169±0.064 vs 0.108±0.028 g/L, t=-4.176, P=0.001), apoE (0.054±0.028vs 0.043±0.009 g/L, t=-3.177, P=0.002) increased in the hypertriglyceridemias combined with correlated with all apos; triglyceride (TG) was positively correlated with apoB (r=0.349, P＜0.01),apoC2 (r=0.517, P＜0.01), apoC3 (r=0.746, P ＜0.01) and apoE (r=0.621, P＜0.01) , HDL-C was positively correlated with apoA1 (r=0.873, P＜0.01), apoA2 (r=0.494, P＜0.01) and negatively correlated with apoC2 (r=-0.152, P＜0.05); low density lipoprotein-cholesteremias (LDL-C) was positively correlated with apoA2 (r=0.295, P＜0.01), apoB (r=0.864, P＜0.01)and apoE (r=0.273, P＜0.01). Conclusions Among 180 male military pilots, serum apoA2,apoB, apoC3 and apoE were related to age, all apolipoproteins were closely associated with lipid disorders.
