中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2010年
12期
11-13
,共3页
先兆子痫%高血压%瘦素
先兆子癇%高血壓%瘦素
선조자간%고혈압%수소
Pre-eclampsia%Hypertension%Leptin
目的 探讨子痫前期患者胎盘组织瘦素的表达水平与病情的关系.方法 选择妊娠期高血压疾病患者10例、子痫前期轻度患者10例、子痫前期重度患者10例,采用RT-PCR技术检测患者胎盘组织瘦素mRNA的表达水平,并与15例正常孕妇(对照者)进行比较.同时检测子痫前期患者24 h尿蛋白定量及平均动脉压.结果 胎盘组织瘦素mRNA表达水平子痫前期重度患者(0.507±0.036)及子痫前期轻度患者(0.476±0.023)均高于对照者(0.441±0.030)(P＜0.01),子痫前期重度患者高于子痫前期轻度患者(P＜0.05);妊娠期高血压疾病患者瘦素mRNA表达水平(0.463±0.024)与对照者比较,差异无统计学意义(P＞0.05).子痫前期患者胎盘组织瘦素mRNA表达水平与24 h尿蛋白定量、平均动脉压呈正相关(P＜0.05).结论 子痫前期患者胎盘组织瘦素表达水平明显升高,且表达水平与病情有关.
目的 探討子癇前期患者胎盤組織瘦素的錶達水平與病情的關繫.方法 選擇妊娠期高血壓疾病患者10例、子癇前期輕度患者10例、子癇前期重度患者10例,採用RT-PCR技術檢測患者胎盤組織瘦素mRNA的錶達水平,併與15例正常孕婦(對照者)進行比較.同時檢測子癇前期患者24 h尿蛋白定量及平均動脈壓.結果 胎盤組織瘦素mRNA錶達水平子癇前期重度患者(0.507±0.036)及子癇前期輕度患者(0.476±0.023)均高于對照者(0.441±0.030)(P＜0.01),子癇前期重度患者高于子癇前期輕度患者(P＜0.05);妊娠期高血壓疾病患者瘦素mRNA錶達水平(0.463±0.024)與對照者比較,差異無統計學意義(P＞0.05).子癇前期患者胎盤組織瘦素mRNA錶達水平與24 h尿蛋白定量、平均動脈壓呈正相關(P＜0.05).結論 子癇前期患者胎盤組織瘦素錶達水平明顯升高,且錶達水平與病情有關.
목적 탐토자간전기환자태반조직수소적표체수평여병정적관계.방법 선택임신기고혈압질병환자10례、자간전기경도환자10례、자간전기중도환자10례,채용RT-PCR기술검측환자태반조직수소mRNA적표체수평,병여15례정상잉부(대조자)진행비교.동시검측자간전기환자24 h뇨단백정량급평균동맥압.결과 태반조직수소mRNA표체수평자간전기중도환자(0.507±0.036)급자간전기경도환자(0.476±0.023)균고우대조자(0.441±0.030)(P＜0.01),자간전기중도환자고우자간전기경도환자(P＜0.05);임신기고혈압질병환자수소mRNA표체수평(0.463±0.024)여대조자비교,차이무통계학의의(P＞0.05).자간전기환자태반조직수소mRNA표체수평여24 h뇨단백정량、평균동맥압정정상관(P＜0.05).결론 자간전기환자태반조직수소표체수평명현승고,차표체수평여병정유관.
Objective To study the relationship of placental expression of leptin and disease development in patients with pre-eclampsia.Methods The placental expression of leptin gene was determined in gestational hypertension(10 cases),mild pre-eclampsia(10 cases),Severe pre-eclampsia(10cases)and normal pregnant women(15 cases,control group)by reverse txanscription/polymerase chain reaction(RT/PCR).Meanwhile,24 hour urine protein and mean arterial blood pressure(MAP)were detected in patients with pre-eclampsia.Results The expression of leptin mRNA in placenta were significantly higher in severe and mild pre-eclarnpsia than that in normal pregnant women(0.507 ±0.036,0.476±0.023vs 0.441 ±0.030)(P＜0.01),meanwhile,in the severe pre-eclampsia was higher than that in the mild preeclampsia(P＜0.05).The difference was not significant between the gestafional hypertension(0.463±0.024)and the normal pregnant women(P＞0.05).There was a positive correlation between the placental leptin mRNA expression levels in pre-eclampsia and the 24 hour urine protein and MAP (P＜0.05).Conclusions The placental leptin mRNA expression levels in pre-eclampsia increase.The pre-eclampsia women placental hptin mRNA expression levels correlate with pathogenetie condition.The placental leptin mRNA expression levels in pre-eclampsia correlate,with disease development.
