CAJ | 학술논문

目的探讨氯吡格雷对急性脑梗死患者血浆溶血磷脂酸(LPA)水平及血小板功能的影响.方法选择明确诊断的急性脑梗死患者62例,完全随机分为2组:氯吡格雷组30例,除常规治疗外口服氯吡格雷75 mg/d;对照组32例,根据病情适当给予脱水、胞二磷胆碱营养脑细胞等常规治疗.分别测定2组患者治疗前及治疗2周后LPA水平,同时进行神经功能缺损评分.结果 2组血浆LPA水平及神经功能缺损评分较同组治疗前均明显下降,差异有统计学意义(P<0.01);氯吡格雷组治疗后血浆LPA水平及神经功能缺损评分均较对照组治疗后明显下降,差异有统计学意义(P<0.01).结论氯吡格雷能有效降低血浆LPA水平,降低神经功能缺损评分.
목적 탐토록필격뢰대급성뇌경사환자혈장용혈린지산(LPA)수평급혈소판공능적영향.방법 선택명학진단적급성뇌경사환자62례,완전수궤분위2조:록필격뢰조30례,제상규치료외구복록필격뢰75 mg/d;대조조32례,근거병정괄당급여탈수、포이린담감영양뇌세포등상규치료.분별측정2조환자치료전급치료2주후LPA수평,동시진행신경공능결손평분.결과 2조혈장LPA수평급신경공능결손평분교동조치료전균명현하강,차이유통계학의의(P<0.01);록필격뢰조치료후혈장LPA수평급신경공능결손평분균교대조조치료후명현하강,차이유통계학의의(P<0.01).결론 록필격뢰능유효강저혈장LPA수평,강저신경공능결손평분.
Objective To observe the influence of Clopidogre on lysophosphatidic acid (LPA) in acute cerebral infarction. Methods Sixty-two cases of acute cerebral infarction were enrolled, including 30 cases of ther-apeutic group, 32 cases in control group. In the therapeutic group the patients had dehydration, neurotrophic agents and clopidogrel 75 mg/d. The concentration of LPA was measured and the degree of neurofunction defect was ana-lyzed before and 2 weeks after treament. Results The level of LPA and degree of neurofuntion defect decreased af-ter treatment in both groups (P>0.01 ) . There was significant difference in therapeutic group compared with con-trols(P<0.01 ). Conclusion Clopidogre decreases lysophosphatidic in acute cerebral infarction.