CAJ | 학술논문

目的评估PMomo曲张精索内静脉结扎术(PV)和改良Palomo曲张精索内静脉结扎术(MPV)对大鼠同侧睾丸的影响.方法检测实验性左侧精索静脉曲张(ELV)组(9只)、PV组(10只)、MPV组(8只)、和对照组(8只)大鼠左侧睾丸的Johnsen's评分、生精小管的超微结构、和生殖细胞凋亡指数(AJ).结果对照组Johnsen's评分(9.46±0.52)显著高于ELV组(7.72±0.31,P＜0.05)和PV组(2.86±0.31,P＜0.01),与MPV组(9.42±0.63)比较差异无统计学意义(P＞0.05);对照组AI(2.21±1.15)显著低于ELV组(5.32±1.23,P＜0.05)和PV组(9.26±1.98,P＜0.01),与MPV组(2.32±1.18)比较差异无统计学意义(P＞0.05);ELV和PV组生精小管的超微结构明显异常.结论 MPV可以修复ELV所导致的同侧睾丸的损伤,PV则使损伤进一步加重.
목적 평고PMomo곡장정색내정맥결찰술(PV)화개량Palomo곡장정색내정맥결찰술(MPV)대대서동측고환적영향.방법 검측실험성좌측정색정맥곡장(ELV)조(9지)、PV조(10지)、MPV조(8지)、화대조조(8지)대서좌측고환적Johnsen's평분、생정소관적초미결구、화생식세포조망지수(AJ).결과 대조조Johnsen's평분(9.46±0.52)현저고우ELV조(7.72±0.31,P＜0.05)화PV조(2.86±0.31,P＜0.01),여MPV조(9.42±0.63)비교차이무통계학의의(P＞0.05);대조조AI(2.21±1.15)현저저우ELV조(5.32±1.23,P＜0.05)화PV조(9.26±1.98,P＜0.01),여MPV조(2.32±1.18)비교차이무통계학의의(P＞0.05);ELV화PV조생정소관적초미결구명현이상.결론 MPV가이수복ELV소도치적동측고환적손상,PV칙사손상진일보가중.
Objective To investigate the effects of Palomo varicocelectomy (PV) and modified Palomo varicocelectomy (MPV) on the ipsilateral testes in rats. Methods The Johnsen's score was re-corded, ultrastructure of seminiferous tubules observed, and germ cell apoptotic index (AI) detected in the left testes in the experimental left varicocele (ELV) group (n = 9), PV group (n = 10), MPV group (n =8) ,and control group (n = 8). Results Johnsen's score in control group (9.46±0.52) was significant-ly higher than that in ELV group (7.72±0.31,P＜0.05) and PV group (2.86±0. 31, P＜0.01), but there was no statistically significant difference between control group and MPV group (9.42±0.63, P＞0.05).Germ cell AI in control group (2.21±1.15) was significantly lower than that in ELV group(5.32±1.23, P＜0.05) and PV group (9.26±1.98, P＜0.01), but had no statistically significant difference from that in MPV group (2.21±1.15 ,P＞0.05). Ultrastructural abnormalities of seminiferous tubules were observed in PV and ELV groups. Conclusion The MPV can repair the varicocole-induced lesion on the ipsilateral testes,but the PV can aggravate the injury.