中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2012年
1期
14-16
,共3页
长寿命浆细胞%特发性血小板减少性紫癜%预后
長壽命漿細胞%特髮性血小闆減少性紫癜%預後
장수명장세포%특발성혈소판감소성자전%예후
Long- lived plasma cells%Idiopathic thrombocytopenic purpura%Prognosis
目的 探讨长寿命浆细胞与特发性血小板减少性紫癜(ITP)患者预后,及其与相关临床指标的关系.方法 用流式细胞术检测100例初诊ITP患者和20倒正常对照者外周血长寿命浆细胞表达率.随访6个月后,将ITP患者分为急性型与慢性型两组,比较初诊时外周血长寿命浆细胞表达率,并分析长寿命浆细胞表达率与就诊时间、初诊时血小板计数、血小板相关抗体、骨髓巨核细胞计数、治疗反应的关系.结果 外周血长寿命浆细胞表达率,急性型组与对照组比较差异无统计学意义(P＞0.05),慢性型组明显高于对照组,差异有统计学意义(P＜0.05)；慢性型患者外周血长寿命浆细胞表达率与初诊时血小板计数、血小板相关抗体无相关(P＞0.05),与就诊时间、骨髓巨核细胞计数、治疗反应相关(P＜0.05).结论 长寿命浆细胞在慢性型ITP患者外周血中高表达,可作为早期判断ITP患者预后的重要指标之一.
目的 探討長壽命漿細胞與特髮性血小闆減少性紫癜(ITP)患者預後,及其與相關臨床指標的關繫.方法 用流式細胞術檢測100例初診ITP患者和20倒正常對照者外週血長壽命漿細胞錶達率.隨訪6箇月後,將ITP患者分為急性型與慢性型兩組,比較初診時外週血長壽命漿細胞錶達率,併分析長壽命漿細胞錶達率與就診時間、初診時血小闆計數、血小闆相關抗體、骨髓巨覈細胞計數、治療反應的關繫.結果 外週血長壽命漿細胞錶達率,急性型組與對照組比較差異無統計學意義(P＞0.05),慢性型組明顯高于對照組,差異有統計學意義(P＜0.05)；慢性型患者外週血長壽命漿細胞錶達率與初診時血小闆計數、血小闆相關抗體無相關(P＞0.05),與就診時間、骨髓巨覈細胞計數、治療反應相關(P＜0.05).結論 長壽命漿細胞在慢性型ITP患者外週血中高錶達,可作為早期判斷ITP患者預後的重要指標之一.
목적 탐토장수명장세포여특발성혈소판감소성자전(ITP)환자예후,급기여상관림상지표적관계.방법 용류식세포술검측100례초진ITP환자화20도정상대조자외주혈장수명장세포표체솔.수방6개월후,장ITP환자분위급성형여만성형량조,비교초진시외주혈장수명장세포표체솔,병분석장수명장세포표체솔여취진시간、초진시혈소판계수、혈소판상관항체、골수거핵세포계수、치료반응적관계.결과 외주혈장수명장세포표체솔,급성형조여대조조비교차이무통계학의의(P＞0.05),만성형조명현고우대조조,차이유통계학의의(P＜0.05)；만성형환자외주혈장수명장세포표체솔여초진시혈소판계수、혈소판상관항체무상관(P＞0.05),여취진시간、골수거핵세포계수、치료반응상관(P＜0.05).결론 장수명장세포재만성형ITP환자외주혈중고표체,가작위조기판단ITP환자예후적중요지표지일.
Objective To investigate the relationship of the long -lived plasma cells and the prognosis of patients with idiopathic thrombocytopenic purpura ( ITP),and the relationship with ITP's relevant clinical indicators.Methods The expression rate of long - lived plasma cell in peripheral blood of 100 patients with preliminary diagnosis of ITP and 20 normal controls were assayed by flow cytometry.After follow - up of six months,the ITP patients were divided into acute - type and chronic - type two groups,the expression rate of long - lived plasma cells in peripheral blood when preliminary diagnosed were compared,and the relationships between expression rate and treatment time,platelet count when preliminary diagnosis,platelet- associated antibody,bone marrow megakaryocyte count,therapeutic reaction were analyzed.Results Expression rate of long - lived plasma cells in peripheral blood had no significant difference (P ＞ 0.05 ) in acute -type group and the control group,and it was significantly higher in chronic -type group than that in control type,the difference was statistically significant (P ＜0.05 ) ; Expression rate of long - lived plasma cells in peripheral blood in chronic - type group had no correlation with platelet count when preliminary diagnosis and platelet - associated antibodies (P ＞0.05 ),and was correlated with the treatment time,bone marrow megakaryocyte count,therapeutic reaction (P ＜ 0.05).Conclusions Long - lived plasma cells in peripheral blood of patients with chronic ITP patients has high expression,which can be used as one of the important indicators for early determination of the prognosis of patients with ITP.
